Citations for
1CASP2, CRADD, PIDD1
PIDD mediates and stabilizes the interaction between RAIDD and caspase-2 for the PIDDosome assembly.
Jang TH, Park HH.
BMB Rep 46(9):471-6. 2013
2CASP2
Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.
Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K.
EMBO J 31(11):2615-28. doi: 10.1038/emboj.2012.93. 2012
3CASP2, CRADD
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM.
Biochem J 444(3):591-9. doi: 10.1042/BJ20111588. 2012
4CASP2
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, Kumar S.
Cell Death Differ 19(8):1288-98. doi: 10.1038/cdd.2012.36. Epub 2012 Apr 13. Erratum in: Cell Death Differ. 2012 Aug;19(8):1411. 2012
5CASP2
Caspase-2: the orphan caspase.
Bouchier-Hayes L, Green DR.
Cell Death Differ 19(1):51-7. doi: 10.1038/cdd.2011.157. Epub 2011 Nov 11. Review. 2012
6CASP2, PIDD1
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T.
Mol Cell 43(1):57-71. 2011
7CASP2
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
Sohn D, Budach W, Jänicke RU.
Cell Death Differ 18(10):1664-74. doi: 10.1038/cdd.2011.34. Epub 2011 Apr 8. 2011
8CASP2
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.
Yoo BH, Wang Y, Erdogan M, Sasazuki T, Shirasawa S, Corcos L, Sabapathy K, Rosen KV.
J Biol Chem 286(45):38894-903. doi: 10.1074/jbc.M111.290692. Epub 2011 Sep 8. 2011
9CASP2
Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity.
Coe LM, Lippner D, Perez GI, McCabe LR.
J Cell Biochem 112(9):2403-11. doi: 10.1002/jcb.23163. 2011
10CASP2
Caspase 2-mediated tumor suppression involves survivin gene silencing.
Guha M, Xia F, Raskett CM, Altieri DC.
Oncogene 29(9):1280-92. doi: 10.1038/onc.2009.428. Epub 2009 Nov 23. 2010
11CASP2, CASP5
Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.
Babas E, Ekonomopoulou MT, Karapidaki I, Doxakis A, Betsas G, Iakovidou-Kritsi Z.
Int J Gynecol Cancer 20(8):1381-5. doi: 10.1111/IGC.0b013e3181ed7896. 2010
12CASP2
A tumor suppressor function for caspase-2.
Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S.
Proc Natl Acad Sci U S A 106(13):5336-41. Epub 2009 Mar 11. 2009
13CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Kim YR, Kim KM, Yoo NJ, Lee SH.
Hum Pathol 40(6):868-71. Epub 2009 Mar 9. 2009
14CASP2, PKCZ
PKC zeta controls DNA topoisomerase-dependent human caspase-2 pre-mRNA splicing.
Solier S, De Cian MC, Bettaieb A, Desoche L, Solary E, Corcos L.
FEBS Lett 582(2):372-378. Epub 2007 Dec 31. 2008
15CASP2, PIDD1
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
Baptiste-Okoh N, Barsotti AM, Prives C.
Proc Natl Acad Sci U S A 105(6):1937-42. Epub 2008 Jan 31. 2008
16CASP2, RBM5
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.
Fushimi K, Ray P, Kar A, Wang L, Sutherland LC, Wu JY.
Proc Natl Acad Sci U S A 105(41):15708-13. Epub 2008 Oct 7. 2008
17CASP2, PRKCZ
PKC zeta controls DNA topoisomerase-dependent human caspase-2 pre-mRNA splicing.
Solier S, De Cian MC, Bettaieb A, Desoche L, Solary E, Corcos L.
FEBS Lett 582(2):372-8. Epub 2007 Dec 31. Erratum in: FEBS Lett. 2008 Feb 20;582(4):536. PMID: 18166155 2008
18CASP2
Caspase-2 is required for cell death induced by cytoskeletal disruption.
Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S.
Oncogene 27(24):3393-404. Epub 2008 Jan 14.PMID: 18193089 2008
19CASP2, TRAF2, RALBP1
A novel caspase-2 complex containing TRAF2 and RIP1.
Lamkanfi M, D'hondt K, Vande Walle L, van Gurp M, Denecker G, Demeulemeester J, Kalai M, Declercq W, Saelens X, Vandenabeele P.
J Biol Chem 280(8):6923-32. Epub 2004 Dec 8. 2005
20CASP2
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization.
Lassus P, Opitz-Araya X, Lazebnik Y.
Science 297(5585):1352-4. 2002
21CASP2, CRADD
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES.
J Biol Chem 277(16):13430-7. Epub 2002 Feb 6. 2002
22CASP2
Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3' acceptor site.
Cote J, Dupuis S, Jiang Z, Wu JY.
Proc Natl Acad Sci U S A 98(3):938-43. 2001
23CASP2
Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.
Jiang ZH, Zhang WJ, Rao Y, Wu JY.
Proc Natl Acad Sci U S A 95(16):9155-60. 1998
24CASP2
Defects in regulation of apoptosis in caspase-2-deficient mice.
Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan J.
Genes Dev 12(9):1304-14. 1998
25CASP1, CASP2, CASP3, CASP4, CASP6, CASP7
Caspases: intracellular signaling by proteolysis.
Salvesen GS, Dixit VM.
Cell 91(4):443-6. 1997
26CASP1, CASP2, CASP3, CASP6, CASP7
Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis.
Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA.
Biochem Biophys Res Commun 225(3):983-9. 1996
27CASP2
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms.
Kumar S, et al.
Hum Genet 95 : 641-644. 1995
28CASP2
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.
Wang L, et al.
Cell 78 : 739-750. 1994