basic FUNCTION
| cysteine containing aspartate-specific protease, mammalian interleukin 1 beta convertase, promoting apoptosis |
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splicing regulation of CASP-2L/CASP-2S may play an important role in neural development |
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required in stress induced apoptosis for permeabilization of mitochondria |
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potent inducer of NF-kappaB and p38 MAPK activation in a TRAF2-mediated way |
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required for apoptosis induced by cytoskeletal disruption, having a context-dependent function  |
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role of caspase-2 as a tumor suppressor appears to be unique among mammalian caspases  |
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functions as an endogenous inhibitor of NFkappaB-dependent cell survival and this mechanism may contribute to tumor suppression  |
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changes of CASP2 and CASP5 activities could be indicative of their involvement in the cervical malignancy mechanisms  |
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its expression promotes growth arrest and chemotherapy resistance by a mechanism that depends on CASP2 and wild-type TP53  |
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initiator caspase, which has been implicated to function in apoptotic and non-apoptotic signalling pathways, including cell-cycle regulation, DNA-damage signalling and tumour suppression  |
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neuronally expressed developmentally down-regulated gene required for neuronal death induced by several stimuli, including NGF (nerve growth factor) deprivation and APP (  |
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highly conserved CASP2 is required for pore-forming toxins (PFT)-mediated apoptosis  |
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obligatory role as an initiator caspase during PFT-mediated apoptosis  |
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