| basic FUNCTION
| role in membrane lipid transport ( |
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a key protein in the cellular lipid removal pathway ( |
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ABC transporter, traffic ATPase, facilitator of cellular efflux of cholesterol and phospholipid and key regulator of high density lipoprotein (HDL) metabolism |
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leukocyte factor that controls the recruitment of inflammatory cells and protects against atherosclerosis |
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playing a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages |
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necessary for proper maturation of dense bodies in platelets ( |
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plays a critical role in CNS apoE metabolism ( |
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STX12, FLOT1, and ABCA1 were identified as phagosomal proteins, indicating the involvement of the phagosomal compartment in ABCA1-mediated lipid efflux |
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glial ABCA1 required for cholesterol efflux to apoA-I and plays a key role in facilitating cholesterol efflux to apoE ( |
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a critical role for intestinal ABCA1 in plasma HDL biogenesis in vivo ( |
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secrete several species of sphingomyelin and phosphatidylcholine ( |
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regulating MEGF10 (function of MEGF10 is modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7) |
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playing an important role in lipid transport in Sertoli cells and influencing male fertility |
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role in transport of cholesterol and phospholipids to nascent HDL particles and plays a central role in lipoprotein metabolism and macrophage cholesterol homeostasis |
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contributes to transport maternal cholesterol to the developing fetus |
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plays a role in the oligomerization and Golgi exit of caveolin-1 during cholesterol efflux in aortic endothelial cells after HDL stimulation |
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ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis |
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mediates the rate-limiting step in high density lipoprotein (HDL) particle formation |
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critical importance of the rate of flux of cholesterol out of lysosomes in the regulation of ABCA1 expression and HDL particle formation |
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ABCA1 and ABCG1 each make complimentary and important contributions to beta-cell function by maintaining islet cholesterol homeostasis |
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ABCA1 regulates cellular cholesterol at two levels, and cholesterol regulation functions are likely essential for PRKACA activation by ABCA1 |
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directly promotes the anti-inflammatory arm of the immune response |
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sterol transporters ABCA1, ABCG5, and ABCG8 may play a role in the pathogenesis of cholesterol-related gallbladder diseases (CAGD) |
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ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane |
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is a key macromolecule facilitating bidirectional sterol movement at the plasma membrane (PM) and ABCA1 controls retrograde sterol transport by modulating a certain clathrin-independent endocytic process |
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novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix |
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maintains optimal hepatocyte Plasma membrane (PM) free cholesterol (FC), through intracellular FC trafficking, for efficient insulin signaling 2) |
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membrane transporter that facilitates nascent HDL formation |
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important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly |
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affects placental function via trophoblast and macrophage |
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ABCA1 and ABCG1, are essential for maintaining lipid homeostasis in cells such as macrophages by exporting excess cholesterol to extracellular acceptors |
