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FLASH GENE

Symbol

OPRK1

contributors: mct - updated : 27-01-2016

HGNC name	opioid receptor, kappa 1
HGNC id	8154

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   OPRK1 promoter hypermethylation might increase the risk of Alzheimer through its regulation on the gene expression of OPRK1

Susceptibility

to opiate addiction to alcohol dependence

Variant & Polymorphism SNP , other	36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects
	polymorphisms increasing the risk of alcohol dependence

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual anterior chamber agonists reduce intraocular pression by reducing aqueous humor formation and increasing aqueous humor outflow, thereby suggesting their possible usefulness in glaucoma therapy

ANIMAL & CELL MODELS

Oprk1 stimulation inhibits TLR4/NfkB signaling in the rat heart subjected to myocardial ischemia and reperfusion (MI/R)