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FLASH GENE
Symbol PMP2 contributors: SGE/npt - updated : 31-05-2010
HGNC name peripheral myelin protein 2
HGNC id 9117
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pmp2 (87.1pc)
homolog to rattus Pmp2 (90.2pc)
Homologene
FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
    • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potentially involved in the transport of fatty acids or metabolism of myelin lipids
  • acting synergistically with MBP to cause stacking of lipid bilayers (Suresh 2010)
  • lipid binding activity (Hayasaka 1991)
  • may play a role in lipid transport protein in Schwann cells
  • forms a beta-barrel structure that accomodates hydrophobic ligand in its interior
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • SNP at positions 220 and 445 (Besançon 2001)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS