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FLASH GENE
Symbol PMP2 contributors: SGE/npt - updated : 31-05-2010
HGNC name peripheral myelin protein 2
HGNC id 9117
Location 8q21.13      Physical location : 82.352.563 - 82.359.719
Synonym name
  • myelin P2 protein
  • Synonym symbol(s) MP2, FABP8, M-FABP, P2
    DNA
    TYPE functioning gene
    STRUCTURE 7.16 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PKIA 8q13-q21.3 protein kinase (cAMP-dependent, catalytic) inhibitor alpha CGI-62 8q21.11 CGI-62 protein IL7 8q12-q13 interleukin 7 STMN2 8p13.2 stathmin-like 2 HEY1 8q21 hairy/enhancer-of-split related with YRPW motif 1 MRPS28 8q21.1-q21.2 mitochondrial ribosomal protein S28 TPD52 8q21 tumor protein D52 LOC389671 8 LOC389671 LOC392236 8 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC340443 8q21.12 similar to ribosomal protein S5; 40S ribosomal protein S5 RINZF LOC389672 8 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC392237 8 similar to mitochondrial carrier triple repeat 1 CKS1A 8q21 CDC28 protein kinase regulatory subunit 1A PAG 8q21.13 CDC28 protein kinase regulatory subunit 1A LOC392238 8 LOC392238 LOC392239 FABP5 15q12-q24.3 fatty acid binding protein 5 (psoriasis-associated) PMP2 8q21.3-q22.1 peripheral myelin protein 2 FABP4 8q21 fatty acid binding protein 4, adipocyte LOC389673 8 similar to Myelin P2 protein LOC392240 8 similar to hypothetical protein MGC5466 IMPA1 8q21.2-q21.3 inositol(myo)-1(or 4)-monophosphatase 1 FLJ14007 8q21.13 hypothetical protein FLJ14007 Shax3 8q21.13 Snf7 homologue associated with Alix 3 SNX16 8q21.13 sorting nexin 16 LOC389674 8 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC392241 8 similar to tropomyosin 3, gamma LOC138046 8q21.13 hypothetical protein LOC138046 KIAA1764 8q21.13-q21.2 KIAA1764 protein E2F5 8q21.13 E2F transcription factor 5, p130-binding MGC59868 CA1 8q13-q22.1 carbonic anhydrase I
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3579 - 132 - Hayasaka (1991)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Pmp2 (87.1pc)
    homolog to rattus Pmp2 (90.2pc)
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potentially involved in the transport of fatty acids or metabolism of myelin lipids
  • acting synergistically with MBP to cause stacking of lipid bilayers (Suresh 2010)
  • lipid binding activity (Hayasaka 1991)
  • may play a role in lipid transport protein in Schwann cells
  • forms a beta-barrel structure that accomodates hydrophobic ligand in its interior
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • SNP at positions 220 and 445 (Besanšon 2001)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS