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FLASH GENE
Symbol PMP2 contributors: SGE/npt - updated : 31-05-2010
HGNC name peripheral myelin protein 2
HGNC id 9117
Location 8q21.13      Physical location : 82.352.563 - 82.359.719
Synonym name
  • myelin P2 protein
  • Synonym symbol(s) MP2, FABP8, M-FABP, P2
    DNA
    TYPE functioning gene
    STRUCTURE 7.16 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3579 - 132 - Hayasaka (1991)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Pmp2 (87.1pc)
    homolog to rattus Pmp2 (90.2pc)
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potentially involved in the transport of fatty acids or metabolism of myelin lipids
  • acting synergistically with MBP to cause stacking of lipid bilayers (Suresh 2010)
  • lipid binding activity (Hayasaka 1991)
  • may play a role in lipid transport protein in Schwann cells
  • forms a beta-barrel structure that accomodates hydrophobic ligand in its interior
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • SNP at positions 220 and 445 (Besanšon 2001)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS