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FLASH GENE
Symbol ADRB3 contributors: mct - updated : 06-02-2019
HGNC name adrenergic, beta-3-, receptor
HGNC id 288
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
interspecies homolog to murine Adrb3
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • adrenergic, beta-3-, receptor activating adenylate cyclase
  • is an essential regulator of metabolic and endocrine functions
  • negatively regulate beta-adrenergic signaling via nitric oxide and are dependent on the adipokine leptin for normal expression in adipocytes
  • epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications
  • showed a significantly higher expression and methylation in high and low glucose concentration respectively inthe retina
  • in the kidney may be a new player in sympathetic regulation of renal function
  • is dispensable for cold-induced transcriptional activation in both classical brown and, as opposed to earlier studies, brite/beige cells
  • ADRB3 signals regulate the Mesenchymal stem cells (MSCs) niche, thereby resulting in modulation of endothelial progenitor cells (EPCs) biological features
  • cold temperatures and ADRB3 agonists activate distinct cellular populations that express different beta-adrenergic receptors to induce beige adipogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADRB3-dependent regulation of IL6 expression is well established
  • ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
  • stimulation in human macrophages inhibits NADPHoxidase activity and induces catalase expression via PPARG activation
  • might exert an anti-atherosclerotic effect by upregulating hepatic APOA1 expression and promoting the cholesterol reverse transport process
  • BORCS6 is upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction
    • cell & other
    REGULATION
    Other
  • S-palmitoylated at the canonical site within the C-terminal tail: Cys-361/363
    • ASSOCIATED DISORDERS
    corresponding disease(s) ADRB3
    related resource Obesity at GeneDis (beta-3-adrenergic receptor)
    Susceptibility
  • for hypertension in the Sardinian population and for obesity in Mexican-American population
  • for non insulin dependent type 2 diabetes
  • for obesity
    • Variant & Polymorphism SNP
  • polymorphism W64R
  • allele Arg64 increases the risk of non insulin dependent type 2 diabetes
  • ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is promising, novel targets for anti-cancer therapy
    ANIMAL & CELL MODELS