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FLASH GENE

Symbol

ADRB3

contributors: mct - updated : 06-02-2019

HGNC name	adrenergic, beta-3-, receptor
HGNC id	288

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ADRB3 non insulin dependent diabetes and/or morbid obesity
Location	8p11.23      Physical location : 37.820.515 - 37.824.184
Synonym name	beta-3 adrenoreceptor
Synonym symbol(s)	BAR3, BETA3AR, B3AR, FLJ99960

DNA

TYPE	functioning gene
STRUCTURE	3.67 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000025 2 - 2660 NP_000016 - 408 - 2018 29606859

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Urinary kidney tubule collecting duct     Homo sapiens   kidney nephron renal capsule     Homo sapiens Visual eye retina       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

interspecies

homolog to murine Adrb3

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	adrenergic, beta-3-, receptor activating adenylate cyclase
	is an essential regulator of metabolic and endocrine functions
	negatively regulate beta-adrenergic signaling via nitric oxide and are dependent on the adipokine leptin for normal expression in adipocytes
	epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications
	showed a significantly higher expression and methylation in high and low glucose concentration respectively inthe retina
	in the kidney may be a new player in sympathetic regulation of renal function
	is dispensable for cold-induced transcriptional activation in both classical brown and, as opposed to earlier studies, brite/beige cells
	ADRB3 signals regulate the Mesenchymal stem cells (MSCs) niche, thereby resulting in modulation of endothelial progenitor cells (EPCs) biological features
	cold temperatures and ADRB3 agonists activate distinct cellular populations that express different beta-adrenergic receptors to induce beige adipogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ADRB3-dependent regulation of IL6 expression is well established
	ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
	stimulation in human macrophages inhibits NADPHoxidase activity and induces catalase expression via PPARG activation
	might exert an anti-atherosclerotic effect by upregulating hepatic APOA1 expression and promoting the cholesterol reverse transport process
	BORCS6 is upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction

cell & other

REGULATION

Other

S-palmitoylated at the canonical site within the C-terminal tail: Cys-361/363

ASSOCIATED DISORDERS

corresponding disease(s)

ADRB3

related resource

Obesity at GeneDis (beta-3-adrenergic receptor)

Susceptibility

for hypertension in the Sardinian population and for obesity in Mexican-American population for non insulin dependent type 2 diabetes for obesity

Variant & Polymorphism SNP	polymorphism W64R
	allele Arg64 increases the risk of non insulin dependent type 2 diabetes
	ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     is promising, novel targets for anti-cancer therapy

ANIMAL & CELL MODELS