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FLASH GENE
Symbol ADRB3 contributors: mct - updated : 06-02-2019
HGNC name adrenergic, beta-3-, receptor
HGNC id 288
Corresponding disease
ADRB3 non insulin dependent diabetes and/or morbid obesity
Location 8p11.23      Physical location : 37.820.515 - 37.824.184
Synonym name beta-3 adrenoreceptor
Synonym symbol(s) BAR3, BETA3AR, B3AR, FLJ99960
DNA
TYPE functioning gene
STRUCTURE 3.67 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2660 - 408 - 2018 29606859
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Urinarykidneytubulecollecting duct   Homo sapiens
 kidneynephronrenal capsule   Homo sapiens
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
interspecies homolog to murine Adrb3
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • adrenergic, beta-3-, receptor activating adenylate cyclase
  • is an essential regulator of metabolic and endocrine functions
  • negatively regulate beta-adrenergic signaling via nitric oxide and are dependent on the adipokine leptin for normal expression in adipocytes
  • epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications
  • showed a significantly higher expression and methylation in high and low glucose concentration respectively inthe retina
  • in the kidney may be a new player in sympathetic regulation of renal function
  • is dispensable for cold-induced transcriptional activation in both classical brown and, as opposed to earlier studies, brite/beige cells
  • ADRB3 signals regulate the Mesenchymal stem cells (MSCs) niche, thereby resulting in modulation of endothelial progenitor cells (EPCs) biological features
  • cold temperatures and ADRB3 agonists activate distinct cellular populations that express different beta-adrenergic receptors to induce beige adipogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADRB3-dependent regulation of IL6 expression is well established
  • ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
  • stimulation in human macrophages inhibits NADPHoxidase activity and induces catalase expression via PPARG activation
  • might exert an anti-atherosclerotic effect by upregulating hepatic APOA1 expression and promoting the cholesterol reverse transport process
  • BORCS6 is upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction
  • cell & other
    REGULATION
    Other
  • S-palmitoylated at the canonical site within the C-terminal tail: Cys-361/363
  • ASSOCIATED DISORDERS
    corresponding disease(s) ADRB3
    related resource Obesity at GeneDis (beta-3-adrenergic receptor)
    Susceptibility
  • for hypertension in the Sardinian population and for obesity in Mexican-American population
  • for non insulin dependent type 2 diabetes
  • for obesity
  • Variant & Polymorphism SNP
  • polymorphism W64R
  • allele Arg64 increases the risk of non insulin dependent type 2 diabetes
  • ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is promising, novel targets for anti-cancer therapy
    ANIMAL & CELL MODELS