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FLASH GENE

Symbol

JAK2

contributors: mct/shn - updated : 20-06-2016

HGNC name	Janus kinase 2
HGNC id	6192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Jak2-deficient mice are lethal at embryonic stage due to the absence of definitive erythropoiesis (
	Jak2-/- mouse embryos are anemic and die around day 12.5 postcoitum because of absence of definitive erythropoiesis (
	GnRH neuron-specific Jak2 conditional knock-out mice display reduced GnRH mRNA levels, reduced secretion of GnRH and basal serum luteinizing hormone (LH) levels are ignificantly lower in female. Female Jak2 G(-/-) mice exhibit significantly delayed puberty and first estrus, abnormal estrous cyclicity, and impaired fertility (