| 1 | JAK1, JAK2
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| Loss of JAK1 Drives Innate Immune Deficiency.
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| Witalisz-Siepracka A, Klein K, Prinz D, Leidenfrost N, Schabbauer G, Dohnal A, Sexl V.
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| Front Immunol. Jan 8;9:3108. doi: 10.3389/fimmu.2018.03108. eCollection 2018 2019
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| 2 | JAK1, JAK2
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| Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling.
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| Raivola J, Haikarainen T, Silvennoinen O.
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| Cancers (Basel) Dec 27;12(1):78. doi: 10.3390/cancers12010078 2019
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| 3 | JAK1, JAK2, SOCS1
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| Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.
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| Liau NPD, Babon JJ.
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| Methods Mol Biol. 1725:267-280. doi: 10.1007/978-1-4939-7568-6_21 2018
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| 4 | JAK2, NIN
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| JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.
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| Jay J, Hammer A, Nestor-Kalinoski A, Diakonova M.
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| Mol Cell Biol 35(1):111-31. doi: 10.1128/MCB.01138-14. Epub 2014 Oct 20.
2015
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| 5 | CD274, IFNG, JAK1, JAK2
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| Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression.
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| Bellucci R, Martin A, Bommarito D, Wang K, Hansen SH, Freeman GJ, Ritz J.
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| Oncoimmunology Mar 2;4(6):e1008824. doi: 10.1080/2162402X.2015.1008824. eCollection 2015 Jun. 2015
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| 6 | CCDC80, JAK2
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| Identification of Steroid-Sensitive Gene-1/Ccdc80 as a JAK2-Binding Protein.
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| O'Leary EE, Mazurkiewicz-Muñoz AM, Argetsinger LS, Maures TJ, Huynh HT, Carter-Su C.
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| Mol Endocrinol 27(4):619-34. doi: 10.1210/me.2011-1275. Epub 2013 Feb 28.
2013
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| 7 | JAK2, SLC34A1
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| Stimulation of Na(+) coupled phosphate transporter NaPiIIa by janus kinase JAK2.
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| Shojaiefard M, Hosseinzadeh Z, Pakladok T, Bhavsar SK, Lang F.
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| Biochem Biophys Res Commun 431(2):186-91. doi: 10.1016/j.bbrc.2012.12.137. Epub 2013 Jan 9.
2013
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| 8 | JAK2, SLC6A12
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| Up-regulation of the betaine/GABA transporter BGT1 by JAK2.
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| Hosseinzadeh Z, Shojaiefard M, Bhavsar SK, Lang F.
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| Biochem Biophys Res Commun 420(1):172-7. doi: 10.1016/j.bbrc.2012.02.137. Epub 2012 Mar 3.
2012
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| 9 | JAK2, SLC5A3
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| Down-regulation of the myoinositol transporter SMIT by JAK2.
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| Hosseinzadeh Z, Bhavsar SK, Lang F.
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| Cell Physiol Biochem 30(6):1473-80. doi: 10.1159/000343335. Epub 2012 Nov 30.
2012
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| 10 | JAK2, LCK, LMO2
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| Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene.
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| Venkitachalam S, Chueh FY, Yu CL.
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| Biochem Biophys Res Commun 417(3):1058-62. doi: 10.1016/j.bbrc.2011.12.095. Epub 2011 Dec 27.
2012
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| 11 | EPO, EPOR, JAK2, SH2B1
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| The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.
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| Javadi M, Hofstätter E, Stickle N, Beattie BK, Jaster R, Carter-Su C, Barber DL.
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| J Biol Chem 287(31):26223-34. doi: 10.1074/jbc.M112.382721. Epub 2012 Jun 5.
2012
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| 12 | IFNGR2, JAK2
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| Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.
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| Conti L, De Palma R, Rolla S, Boselli D, Rodolico G, Kaur S, Silvennoinen O, Niccolai E, Amedei A, Ivaldi F, Clerico M, Contessa G, Uccelli A, Durelli L, Novelli F.
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| J Immunol 188(3):1011-8. doi: 10.4049/jimmunol.1004013. Epub 2012 Jan 4.
2012
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| 13 | CLCN2, JAK2
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| Downregulation of ClC-2 by JAK2.
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| Hosseinzadeh Z, Bhavsar SK, Lang F.
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| Cell Physiol Biochem 29(5-6):737-42. doi: 10.1159/000178560. Epub 2012 May 11.
2012
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| 14 | FIP1L1, JAK2, PDGFRA
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| Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.
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| Li B, Zhang G, Li C, He D, Li X, Zhang C, Tang F, Deng X, Lu J, Tang Y, Li R, Chen Z, Duan C.
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| PLoS One 7(4):e34912. doi: 10.1371/journal.pone.0034912. Epub 2012 Apr 16.
2012
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| 15 | JAK2
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| The JAK2 46/1 haplotype in Budd-Chiari syndrome and portal vein thrombosis.
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| Smalberg JH, Koehler E, Darwish Murad S, Plessier A, Seijo S, Trebicka J, Primignani M, de Maat MP, Garcia-Pagan JC, Valla DC, Janssen HL, Leebeek FW; European Network for Vascular Disorders of the Liver (EN-Vie).
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| Blood 117(15):3968-73. Epub 2011 Mar 1.
2011
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| 16 | BCR, JAK2
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| Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia.
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| Samanta A, Perazzona B, Chakraborty S, Sun X, Modi H, Bhatia R, Priebe W, Arlinghaus R.
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| Leukemia 25(3):463-72. Epub 2010 Dec 24.
2011
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| 17 | JAK2
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| Jak2 is necessary for neuroendocrine control of female reproduction.
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| Wu S, Divall S, Hoffman GE, Le WW, Wagner KU, Wolfe A.
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| J Neurosci. 31(1):184-92. 2011
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| 18 | JAK2, PRV
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| Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations.
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| Passamonti F, Elena C, Schnittger S, Skoda RC, Green AR, Girodon F, Kiladjian JJ, McMullin MF, Ruggeri M, Besses C, Vannucchi AM, Lippert E, Gisslinger H, Rumi E, Lehmann T, Ortmann CA, Pietra D, Pascutto C, Haferlach T, Cazzola M.
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| Blood 117(10):2813-6. Epub 2011 Jan 11.
2011
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| 19 | JAK2
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| JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma.
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| Van Roosbroeck K, Cox L, Tousseyn T, Lahortiga I, Gielen O, Cauwelier B, De Paepe P, Verhoef G, Marynen P, Vandenberghe P, De Wolf-Peeters C, Cools J, Wlodarska I.
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| Blood 117(15):4056-64. Epub 2011 Feb 15.
2011
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| 20 | JAK2, SLC5A1
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| Stimulation of the glucose carrier SGLT1 by JAK2.
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| Hosseinzadeh Z, Bhavsar SK, Shojaiefard M, Saxena A, Merches K, Sopjani M, Alesutan I, Lang F.
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| Biochem Biophys Res Commun 408(2):208-13. Epub 2011 Mar 21.
2011
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| 21 | CDKN1B, JAK2
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| Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
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| Jäkel H, Weinl C, Hengst L.
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| Oncogene 30(32):3502-12. doi: 10.1038/onc.2011.68. Epub 2011 Mar 21.
2011
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| 22 | ECYT2, JAK2, VHL
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| Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
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| Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL, Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M.
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| Nat Med 17(7):845-53. doi: 10.1038/nm.2370.
2011
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| 23 | ACE2, JAK2, SLC6A19, TMEM27
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| Stimulation of the amino acid transporter SLC6A19 by JAK2.
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| Bhavsar SK, Hosseinzadeh Z, Merches K, Gu S, Bröer S, Lang F.
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| Biochem Biophys Res Commun 414(3):456-61. Epub 2011 Sep 19.
2011
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| 24 | JAK2
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| The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.
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| Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O.
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| Nat Struct Mol Biol 18(9):971-6. doi: 10.1038/nsmb.2099.
2011
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| 25 | ASB2, JAK2
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| Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes
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| Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun XH.
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| Cell Res. May;21(5):754-69. doi: 10.1038/cr.2010.165. Epub 2010 Nov 30. 2011
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| 26 | CRLF2, JAK2
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| CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis.
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| Roll JD, Reuther GW.
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| Cancer Res 70(19):7347-52. Epub 2010 Aug 31. Review.PMID: 20807819 2010
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| 27 | JAK2
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| Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.
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| Cheng MB, Zhang Y, Zhong X, Sutter B, Cao CY, Chen XS, Cheng XK, Zhang Y, Xiao L, Shen YF.
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| Cell Signal. 22(8):1206-13. 2010
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| 28 | JAK2
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| A JAK2-V617F activating mutation in addition to KIT and FLT3 mutations is associated with clinical outcome in patients with t(8;21)(q22;q22) acute myeloid leukemia.
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| Iwanaga E, Nanri T, Matsuno N, Kawakita T, Mitsuya H, Asou N.
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| Haematologica 94(3):433-5. Epub 2009 Jan 30. No abstract available.
2009
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| 29 | AMKLDS, JAK2
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| Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
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| Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR.
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| Br J Haematol 144(6):930-2. Epub 2008 Dec 20. 2009
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| 30 | AMKLDS, JAK2
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| Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.
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| Kearney L, Gonzalez De Castro D, Yeung J, Procter J, Horsley SW, Eguchi-Ishimae M, Bateman CM, Anderson K, Chaplin T, Young BD, Harrison CJ, Kempski H, So CW, Ford AM, Greaves M.
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| Blood 113(3):646-8. Epub 2008 Oct 16.
2009
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| 31 | JAK2, MPD
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| JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.
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| Jones AV, Chase A, Silver RT, Oscier D, Zoi K, Wang YL, Cario H, Pahl HL, Collins A, Reiter A, Grand F, Cross NC.
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| Nat Genet 41(4):446-9. Epub 2009 Mar 15.
2009
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| 32 | JAK2, MPD
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| A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
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| Kilpivaara O, Mukherjee S, Schram AM, Wadleigh M, Mullally A, Ebert BL, Bass A, Marubayashi S, Heguy A, Garcia-Manero G, Kantarjian H, Offit K, Stone RM, Gilliland DG, Klein RJ, Levine RL.
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| Nat Genet 41(4):455-9. Epub 2009 Mar 15.
2009
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| 33 | JAK2, MPD
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| A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.
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| Olcaydu D, Harutyunyan A, Jäger R, Berg T, Gisslinger B, Pabinger I, Gisslinger H, Kralovics R.
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| Nat Genet 41(4):450-4. Epub 2009 Mar 15.
2009
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| 34 | FABP4, JAK2
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| Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling.
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| Thompson BR, Mazurkiewicz-Muñoz AM, Suttles J, Carter-Su C, Bernlohr DA.
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| J Biol Chem 284(20):13473-80. Epub 2009 Mar 23.
2009
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| 35 | JAK1, JAK2, JAK3
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| JAK mutations in high-risk childhood acute lymphoblastic leukemia.
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| Mullighan CG, Zhang J, Harvey RC, Collins-Underwood JR, Schulman BA, Phillips LA, Tasian SK, Loh ML, Su X, Liu W, Devidas M, Atlas SR, Chen IM, Clifford RJ, Gerhard DS, Carroll WL, Reaman GH, Smith M, Downing JR, Hunger SP, Willman CL.
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| Proc Natl Acad Sci U S A 106(23):9414-8. Epub 2009 May 22.
2009
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| 36 | BCR, JAK2
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| A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia.
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| Cirmena G, Aliano S, Fugazza G, Bruzzone R, Garuti A, Bocciardi R, Bacigalupo A, Ravazzolo R, Ballestrero A, Sessarego M.
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| Cancer Genet Cytogenet 183(2):105-8.
2008
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| 37 | JAK2, STAT2, STAT3
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| JAK2/STAT2/STAT3 are required for myogenic differentiation.
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| Wang K, Wang C, Xiao F, Wang H, Wu Z.
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| J Biol Chem 283(49):34029-36. Epub 2008 Oct 2.
2008
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| 38 | JAK2, MPD, MPL, PRV
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| JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science.
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| Kilpivaara O, Levine RL.
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| Leukemia 22(10):1813-7. Epub 2008 Aug 28. Review. 2008
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| 39 | JAK2, MPD, PML, PRV
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| Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy.
|
| Tefferi A.
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| Am J Hematol 83(6):491-7. Review. 2008
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| 40 | JAK2, MPD, MPL
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| Myeloproliferative disorders.
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| Levine RL, Gilliland DG.
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| Blood 112(6):2190-8. Review. 2008
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| 41 | JAK2, SSBP2
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| Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.
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| Poitras JL, Dal Cin P, Aster JC, Deangelo DJ, Morton CC.
|
| Genes Chromosomes Cancer 47(10):884-9.
2008
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| 42 | JAK2, JAK3, MPD, MPL
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| JAK and MPL mutations in myeloid malignancies.
|
| Tefferi A.
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| Leuk Lymphoma 49(3):388-97. Review. 2008
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| 43 | JAK2
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| Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome.
|
| Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A, Shochat C, Cazzaniga G, Biondi A, Basso G, Cario G, Schrappe M, Stanulla M, Strehl S, Haas OA, Mann G, Binder V, Borkhardt A, Kempski H, Trka J, Bielorei B, Avigad S, Stark B, Smith O, Dastugue N, Bourquin JP, Tal NB, Green AR, Izraeli S.
|
| Lancet 372(9648):1484-92. Epub 2008 Sep 19.
2008
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| 44 | JAK2
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| JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.
|
| Plo I, Nakatake M, Malivert L, de Villartay JP, Giraudier S, Villeval JL, Wiesmuller L, Vainchenker W.
|
| Blood 112(4):1402-12. Epub 2008 May 30.PMID: 18515659 2008
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| 45 | JAK2, MPD, PRV
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| JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
|
| Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR, Futreal PA, Erber WN, McMullin MF, Harrison CN, Warren AJ, Gilliland DG, Lodish HF, Green AR.
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| N Engl J Med 356(5):459-68. 2007
|
| 46 | JAK2, MPD
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| Jak2: normal function and role in hematopoietic disorders.
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| Ihle JN, Gilliland DG.
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| Curr Opin Genet Dev 17(1):8-14. Epub 2007 Jan 8. 2007
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| 47 | JAK2, MPD
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| The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation.
|
| Jamieson CH, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL.
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| Proc Natl Acad Sci U S A 103(16):6224-9. Epub 2006 Apr 7. 2006
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| 48 | PRV, JAK2
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| Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome.
|
| Patel RK, Lea NC, Heneghan MA, Westwood NB, Milojkovic D, Thanigaikumar M, Yallop D, Arya R, Pagliuca A, GŠken J, Wendon J, Heaton ND, Mufti GJ.
|
| Gastroenterology 130(7):2031-8. 2006
|
| 49 | JAK2, RPN1
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| Chronic idiopathic myelofibrosis (CIMF) resulting from a unique 3;9 translocation disrupting the janus kinase 2 (JAK2) gene.
|
| Mark HF, Sotomayor EA, Nelson M, Chaves F, Sanger WG, Kaleem Z, Caughron SK.
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| Exp Mol Pathol 81(3):217-23. Epub 2006 Sep 7.
2006
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| 50 | JAK2, MPD
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| A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
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| James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W.
|
| Nature 434(7037):1144-8. 2005
|
| 51 | JAK2, MPD
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| A gain-of-function mutation of JAK2 in myeloproliferative disorders.
|
| Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC.
|
| N Engl J Med 352(17):1779-90. 2005
|
| 52 | BCR, JAK2
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| A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia.
|
| Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A, Wormann B, Haase D, Bohlander SK.
|
| Genes Chromosomes Cancer 44(3):329-33. 2005
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| 53 | JAK1, JAK2
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| Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.
|
| Huang HM, Lin YL, Chen CH, Chang TW.
|
| J Cell Biochem 96(2):361-75. 2005
|
| 54 | CXCR4, JAK2, STAT3
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| Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.
|
| Ahr B, Denizot M, Robert-Hebmann V, Brelot A, Biard-Piechaczyk M.
|
| J Biol Chem 280(8):6692-700. Epub 2004 Dec 22. 2005
|
| 55 | JAK2, PCM1
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| The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.
|
| Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, Laurent G, Dastugue N, Brousset P.
|
| Oncogene 24(48):7248-52. 2005
|
| 56 | CALM1, EPOR, JAK2
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| Calmodulin physically interacts with the erythropoietin receptor and enhances Jak2-mediated signaling.
|
| Kakihana K, Yamamoto M, Iiyama M, Miura O.
|
| Biochem Biophys Res Commun 335(2):424-31. 2005
|
| 57 | HES5, JAK2
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| Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
|
| Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y.
|
| Nat Cell Biol. 6(6):547-54. 2004
|
| 58 | JAK2
|
| Jak2 is involved in c-Myc induction by Bcr-Abl.
|
| Xie S, Lin H, Sun T, Arlinghaus RB.
|
| Oncogene. 21(47):7137-46. 2002
|
| 59 | JAK2, STAT3
|
| ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
|
| Ren Z, Schaefer TS.
|
| J Biol Chem. 277(41):38486-93. 2002
|
| 60 | JAK2
|
| Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.
|
| Frank GD, Saito S, Motley ED, Sasaki T, Ohba M, Kuroki T, Inagami T, Eguchi S.
|
| Mol Endocrinol. 16(2):367-77. 2002
|
| 61 | JAK2
|
| Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.
|
| Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O.
|
| Mol Cell Biol. 22(10):3316-26. 2002
|
| 62 | DNAJA3, JAK2
|
| hTid-1, a human DnaJ protein, modulates the interferon signaling pathway.
|
| Sarkar S, Pollack BP, Lin KT, Kotenko SV, Cook JR, Lewis A, Pestka S.
|
| J Biol Chem 276(52):49034-42. 2001
|
| 63 | BRCA1, JAK2, STAT3
|
| Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.
|
| Gao B, Shen X, Kunos G, Meng Q, Goldberg ID, Rosen EM, Fan S.
|
| FEBS Lett. 488(3):179-84. 2001
|
| 64 | JAK2
|
| TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
|
| Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK.
|
| J Biol Chem. 276(51):47771-4. 2001
|
| 65 | JAK2
|
| The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cells.
|
| Horsch K, Schaller MD, Hynes NE.
|
| Mol Endocrinol. 15(12):2182-96 2001
|
| 66 | JAK2, STAM2
|
| STAM2, a new member of the STAM family, binding to the Janus kinases.
|
| Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K.
|
| FEBS Lett 477(1-2):55-61. 2000
|
| 67 | GHTF, JAK2, STAT3
|
| Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.
|
| Park ES, Kim H, Suh JM, Park SJ, You SH, Chung HK, Lee KW, Kwon OY, Cho BY, Kim YK, Ro HK, Chung J, Shong M.
|
| Mol Endocrinol 14(5):662-70. 2000
|
| 68 | CTLA4, JAK2
|
| Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
|
| Chikuma S, Murakami M, Tanaka K, Uede T.
|
| J Cell Biochem. 78(2):241-50. 2000
|
| 69 | JAK2
|
| Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells.
|
| Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A, Nakauchi H.
|
| Biochem Biophys Res Commun. 272(1):224-9. 2000
|
| 70 | JAK2
|
| SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells.
|
| Wu DW, Stark KC, Dunnington D, Dillon SB, Yi T, Jones C, Pelus LM.
|
| Blood Cells Mol Dis. 26(1):15-24. 2000
|
| 71 | JAK2
|
| Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.
|
| Stofega MR, Argetsinger LS, Wang H, Ullrich A, Carter-Su C.
|
| J Biol Chem. 275(36):28222-9. 2000
|
| 72 | JAK2
|
| Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia.
|
| Cools J, et al.
|
| Cytogenet Cell Genet 85(3-4):260-266. 1999
|
| 73 | JAK2, PRMT5
|
| The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.
|
| Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL, Pestka S.
|
| J Biol Chem 274(44):31531-42. 1999
|
| 74 | JAK2
|
| The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.
|
| Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, Moreno-Ortíz MC, Martínez-A C, Mellado M.
|
| FASEB J. 13(13):1699-710. 1999
|
| 75 | JAK2
|
| The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
|
| Hellgren G, Jansson JO, Carlsson LM, Carlsson B.
|
| Growth Horm IGF Res. 9(3):212-8. 1999
|
| 76 | JAK2
|
| Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.
|
| Yamamoto K, Shibata F, Miura O, Kamiyama R, Hirosawa S, Miyasaka N.
|
| Biochem Biophys Res Commun. 257(2):400-4. 1999
|
| 77 | JAK2
|
| Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.
|
| Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A.
|
| Genes Cells. 4(6):339-51 1999
|
| 78 | JAK2
|
| Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.
|
| Neubauer H, et al.
|
| Cell 93 : 397-409. 1998
|
| 79 | JAK2
|
| Jak2 is essential for signaling through a variety of cytokine receptors.
|
| Parganas E, et al.
|
| Cell 93 : 385-395. 1998
|
| 80 | JAK2
|
| Cloning and characterization of human Jak-2 kinase : high mRNA expression in immune cells and muscle tissue.
|
| Saltzman A, et al.
|
| Biochem Biophys Res Commun 246 : 627-633. 1998
|
| 81 | JAK2
|
| Growth hormone-dependent tyrosine phosphorylation of a GH receptor-associated high molecular WEIGHT protein immunologically related to JAK2.
|
| iang J, et al.
|
| Biochem Biophys Res Commun 253(3):774-9. 1998
|
| 82 | JAK2
|
| Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
|
| Saltzman A, Stone M, Franks C, Searfoss G, Munro R, Jaye M, Ivashchenko Y.
|
| Biochem Biophys Res Commun 246(3):627-33. 1998
|
| 83 | CCR2, JAK2, CCL2
|
| The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
|
| Mellado M, Rodriguez-Frade JM, Aragay A, del Real G, Martin AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martinez-A C.
|
| J Immunol 161(2):805-13. 1998
|
| 84 | JAK2, PTK2
|
| Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.
|
| Zhu T, Goh EL, Lobie PE.
|
| J Biol Chem. 273(17):10682-9. 1998
|
| 85 | JAK2
|
| Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
|
| Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J.
|
| J Biol Chem. 273(26):15906-12. 1998
|
| 86 | JAK2
|
| Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.
|
| Gual P, Baron V, Lequoy V, Van Obberghen E.
|
| Endocrinology. 139(3):884-93. 1998
|
| 87 | JAK2
|
| JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.
|
| Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K.
|
| Blood. 91(7):2264-71. 1998
|
| 88 | JAK2
|
| Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases.
|
| Ratovitski EA, Kotzbauer PT, Milbrandt J, Lowenstein CJ, Burrow CR.
|
| J Biol Chem. 273(6):3654-60. 1998
|
| 89 | JAK2
|
| Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.
|
| Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB.
|
| J Immunol. 160(6):2742-50. 1998
|
| 90 | JAK2
|
| Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription.
|
| Yamashita Y, Watanabe S, Miyazato A, Ohya K, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H.
|
| Blood. 91(5):1496-507. 1998
|
| 91 | ETV6, JAK2
|
| A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia.
|
| Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA.
|
| Science 278(5341):1309-12. 1997
|
| 92 | JAK2
|
| Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.
|
| Zou J, Presky DH, Wu CY, Gubler U.
|
| J Biol Chem. 272(9):6073-7. 1997
|
| 93 | JAK2
|
| Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.
|
| Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C.
|
| Mol Cell Biol. 17(11):6633-44. 1997
|
| 94 | JAK2
|
| Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
|
| Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G.
|
| J Immunol. 158(9):4097-103. 1997
|
| 95 | JAK2
|
| An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.
|
| Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T.
|
| Oncogene. 14(7):751-61 1997
|
| 96 | JAK2
|
| Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase.
|
| Ram PA, Waxman DJ.
|
| J Biol Chem. 272(28):17694-702. 1997
|
| 97 | JAK2
|
| IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
|
| Murata T, Noguchi PD, Puri RK.
|
| J Immunol. 156(8):2972-8. 1996
|
| 98 | JAK2
|
| JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
|
| Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK, Longo DL, Linnekin D.
|
| Blood. 87(9):3688-93. 1996
|
| 99 | JAK2
|
| Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11.
|
| Fuhrer DK, Yang YC.
|
| Biochem Biophys Res Commun. 224(2):289-96. 1996
|
| 100 | JAK2
|
| Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.
|
| Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE.
|
| Nature. 375(6528):247-50. 1995
|
| 101 | JAK2
|
| The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.
|
| Zhao Y, Wagner F, Frank SJ, Kraft AS.
|
| J Biol Chem. 270(23):13814-8. 1995
|
| 102 | JAK2
|
| Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes.
|
| Fuhrer DK, Feng GS, Yang YC.
|
| J Biol Chem. 270(42):24826-30. 1995
|
| 103 | JAK2
|
| Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.
|
| Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, Finbloom DS.
|
| J Biol Chem. 269(20):14333-6. 1994
|
| 104 | JAK1, JAK2
|
| Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.
|
| Pritchard MA, et al.
|
| Mamm Genome 3 : 36-38. 1992
|
| 105 | JAK1, JAK2
|
| Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
|
| Wilks AF, et al.
|
| Mol Cell Biol 11 : 2057-2065. 1991
|