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FLASH GENE

Symbol

MLLT3

contributors: mct/ - updated : 06-06-2014

HGNC name	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
HGNC id	7136

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with HRX (MLL), in acute myeloid/lymphoid, in monoblastic leukemia with granulocytic sarcomas mixed-lineage leukemia and translocation t(9;11)(p22;q23) tumoral   translocation     in acute myeloid/lymphoid, monoblastic leukemia tumoral   translocation     involves MLL, MLLT3, and CCDC94, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate regulator of erythroid/megakaryocytic (E/Meg) lineage decisions (Pina 2008)
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   disruption of interaction between DOT1L and MLLT3/MLLT1 is a promising therapeutic strategy with potentially fewer adverse effects than enzymatic inhibition of DOT1L for KMT2A fusion protein-associated leukemia

ANIMAL & CELL MODELS