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FLASH GENE

Symbol

CHRNB3

contributors: mct - updated : 24-08-2010

HGNC name	cholinergic receptor, nicotinic, beta polypeptide 3
HGNC id	1963

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000749 6 - 1953 NP_000740 - 458 - Koyama (1994)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N terminal extracellular domain
	four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to rattus Chrnb3

Homologene

FAMILY	cholinergic receptor family
	ligand-gated ionic channel (tc 1.a.9) family

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	cholinergic receptor,nicotinic
	ligand gated ion channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to heavy alcohol use to tobacco dependence

Variant & Polymorphism SNP	rs13280604 associated with a composite of the alcohol phenotypes (Hoft 2009)
	SNPs in CHRNB3 were found to be associated to tobacco dependence
	sequence variants associated with smoking behavior (Thorgeirsson 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS