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FLASH GENE
Symbol CHRNB3 contributors: mct - updated : 24-08-2010
HGNC name cholinergic receptor, nicotinic, beta polypeptide 3
HGNC id 1963
Location 8p11.21      Physical location : 42.552.561 - 42.592.209
Synonym name
  • neuronal acetylcholine receptor subunit beta-3
  • acetylcholine receptor, neuronal nicotinic, beta-3 subunit
  • DNA
    TYPE functioning gene
    STRUCTURE 39.65 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1953 - 458 - Koyama (1994)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N terminal extracellular domain
  • four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Chrnb3
    Homologene
    FAMILY
  • cholinergic receptor family
  • ligand-gated ionic channel (tc 1.a.9) family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • cholinergic receptor,nicotinic
  • ligand gated ion channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to heavy alcohol use
  • to tobacco dependence
  • Variant & Polymorphism SNP
  • rs13280604 associated with a composite of the alcohol phenotypes (Hoft 2009)
  • SNPs in CHRNB3 were found to be associated to tobacco dependence
  • sequence variants associated with smoking behavior (Thorgeirsson 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS