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FLASH GENE

Symbol

SDC2

contributors: mct/npt/pgu - updated : 03-02-2016

HGNC name	syndecan 2
HGNC id	10659

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   translocation     involved in a translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses tumoral     --over   in several epithelial-driven colon carcinoma cells, and this up-regulation is necessary for the tumorigenic activity of colon carcinoma cells constitutional       loss of function in microvascular endothelial cells causes impairments in capillary tube-like structures tumoral     --over   in human skin melanoma tissues

Susceptibility

to Leri pleonosteosis

Variant & Polymorphism other	microduplication at 8q22.1 encompassing GDF6 and SDC2 increasing the risk of Leri pleonosteosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS