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FLASH GENE
Symbol SDC2 contributors: mct/npt/pgu - updated : 03-02-2016
HGNC name syndecan 2
HGNC id 10659
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   translocation    
involved in a translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses
tumoral     --over  
in several epithelial-driven colon carcinoma cells, and this up-regulation is necessary for the tumorigenic activity of colon carcinoma cells
constitutional       loss of function
in microvascular endothelial cells causes impairments in capillary tube-like structures
tumoral     --over  
in human skin melanoma tissues
Susceptibility to Leri pleonosteosis
Variant & Polymorphism other
  • microduplication at 8q22.1 encompassing GDF6 and SDC2 increasing the risk of Leri pleonosteosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS