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FLASH GENE
Symbol SDC2 contributors: mct/npt/pgu - updated : 03-02-2016
HGNC name syndecan 2
HGNC id 10659
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal syndecan-2 directly interacts with pro-domain of MMP7
  • cytoplasmic domain implicated in the binding to ezrin, and regulating colon cancer cell migration via interaction with SDCBP
  • PDZ-binding domain in the cytoplasmic region necessary to block the ITGB2 high-affinity conformation, and to reduce cellular adhesion , but cytosolic PDZ-binding domain of SDC2 is not necessary to elicit TCR/CD3 down-regulation
  • extracellular domain of SDC2 is cleaved by MMP7 in various colon cancer cells
  • C-terminal EFYA sequence
  • transmembrane domain of syndecan-2 plays one or more specific roles
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Sdc2
    Homologene
    FAMILY
  • syndecan proteoglycan family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulating tumorigenic activity through regulation of adhesion and proliferation in colon carcinoma cells
  • controls the growth of normal osteoblastic cells
  • inducing osteoblastic cell apoptosis through the JNK/Bax apoptotic pathway, and inducing apoptosis in osteosarcoma cells
  • acting as a suppressor for MMP2 activation, causing suppression of metastasis in at least the metastatic system
  • functions as a docking receptor for MMP7, and might also regulate the activity of MMP7
  • induces spine formation by recruiting intracellular vesicles toward postsynaptic sites through the interaction with TRAPPC4
  • synaptic heparan sulfate proteoglycan that triggers dendritic filopodia and spine formation, and regulates dendritic arborization in cultured hippocampal neurons
  • cell surface heparan sulfate proteoglycan, that is crucial for the tumorigenic activity of colon cancer cells
  • heparan sulfate proteoglycan that has a cell adhesion regulatory domain contained within its extracellular core protein
  • acts to reinforce Notch signaling in smooth muscle cells
  • heparan sulfate proteoglycan that is known to be important for developmental processes, including angiogenesis
  • has a key role in promoting the invasive activity of the cancer cells, in part by regulating the RhoGTPases
  • regulates melanin synthesis and could be a potential therapeutic target for treating melanin-associated diseases
  • cell membrane proteoglycan that can modulate the activity and dynamics of some growth factor receptors and integrins (pMID: 24662262)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • . directly interacts with MMP7
  • interaction with PKCdelta (PKCD) in osteoblasts
  • homodimer interacting with NF1 and CASK
  • SARM1 interacts with and receives signal from SDC2 and controls dendritic arborization through the MKK4-JNK pathway
  • SDCBP interacts with the C-terminal EFYA sequence of SDC2, and thus regulates SDC2-mediated Rac activation and subsequent colon cancer cell migration
  • is a novel ligand for the protein tyrosine phosphatase receptor PTPRJ
  • endothelial cells induce SDC2 expression in smooth muscle cells through Notch signaling, and SDC2 acts as a Notch coreceptor
  • regulates Notch signaling and physically interacts with NOTCH3
  • both NOTCH2 and NOTCH3 can promote SDC2 expression in smooth muscle cells
  • MC1R regulates melanoma cell migration via inhibition of SDC2 expression
  • SDC2 modulates TGFB2 transcriptional regulation via Smad signaling to facilitate fibrosarcoma cell adhesion
  • PEBP1 inhibits syndecan-2 (SDC2), which is aberrantly expressed in breast cancer, via downregulation of HMGA2
  • IL1A regulates extracellular domain shedding of SDC2 through regulation of the MAP kinase-mediated MMP7 expression in colon cancer cells
    • cell & other
  • cell surface associated
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    involved in a translocation t(X,8)(p22.13-q22.1) in a patient with autism and multiple exostoses
    tumoral     --over  
    in several epithelial-driven colon carcinoma cells, and this up-regulation is necessary for the tumorigenic activity of colon carcinoma cells
    constitutional       loss of function
    in microvascular endothelial cells causes impairments in capillary tube-like structures
    tumoral     --over  
    in human skin melanoma tissues
    Susceptibility to Leri pleonosteosis
    Variant & Polymorphism other
  • microduplication at 8q22.1 encompassing GDF6 and SDC2 increasing the risk of Leri pleonosteosis
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS