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FLASH GENE

Symbol

GNB2

contributors: mct - updated : 08-04-2016

HGNC name	guanine nucleotide binding protein (G protein), beta polypeptide 2
HGNC id	4398

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose brown     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a N terminal alpha-helical segment followed by seven WD (Trp-Asp) repeats, forming a propeller structure

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope

basic FUNCTION	playing a role in the release of ATP from human erythrocytes
	in stellate ganglion neurons, GNB2 and GNB4 normally maintain the coupling of Ca(2+) channels with the receptors, with the latter subtype responsible for maintaining the integrity of both pathways
	is required for starvation-induced NFKB1 activation and constitutive NFKB1 activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with ATXN10 (coexpression of ataxin 10 and GNB2 potently activated the Ras-MAP kinase-Elk-1 cascade, a mechanism for inducing neuritogenesis)
	KCNJ6 is capable of interacting with GNB1, GNB2, GNB3 and not GNB4 or GNB5
	GNGT1, GNG2, GNB1, GNB2, GNB3, interacts with MTOR and promotes its activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS