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FLASH GENE

Symbol

HSP90B1

contributors: mct/pg - updated : 16-03-2016

HGNC name	heat shock protein 90kDa beta (Grp94), member 1
HGNC id	12028

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   significantly elevated in intestinal biopsies of Crohn disease (CD)which correlated positively with the degree of inflammation of the tissue

Susceptibility

to bipolar disorder

Variant & Polymorphism SNP	associated with bipolar disorder in a Japanese population

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver targeting HSP90B1 with siRNA induced cell apoptosis and led to the suppression of liver tumor growth immunology autoimmune   potential new therapeutic target in autoimmune diseases

ANIMAL & CELL MODELS

grp94-/- embryos die on day 7 of gestation, fail to develop mesoderm, primitive streak, or proamniotic cavity