| 1 | CLCN1, FKBP8, HSP90B1
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| Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.
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| Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY.
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| Sci Rep 6:32444. doi: 10.1038/srep32444.
2016
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| 2 | HSP90B1, MDM2, TP53
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| Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
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| Wu B, Chu X, Feng C, Hou J, Fan H, Liu N, Li C, Kong X, Ye X, Meng S.
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| Cancer Lett 359(2):325-34. doi: 10.1016/j.canlet.2015.01.034. Epub 2015 Jan 28.
2015
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| 3 | CD109, HSP90B1
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| GP96 is a GARP chaperone and controls regulatory T cell functions.
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| Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z.
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| J Clin Invest 125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20.
2015
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| 4 | HSP90B1, LDLR, PCSK9
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| GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation.
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| Poirier S, Mamarbachi M, Chen WT, Lee AS, Mayer G.
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| Cell Rep 13(10):2064-71. doi: 10.1016/j.celrep.2015.11.006. Epub 2015 Nov 25.
2015
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| 5 | HSP90B1, MZB1
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| MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
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| Rosenbaum M, Andreani V, Kapoor T, Herp S, Flach H, Duchniewicz M, Grosschedl R.
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| Genes Dev 28(11):1165-78. doi: 10.1101/gad.240762.114.
2014
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| 6 | HSP90B1
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| Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.
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| Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles BL, Lee AS.
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| Hepatology 59(3):947-57. doi: 10.1002/hep.26711. Epub 2014 Jan 27.
2014
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| 7 | HSP90B1
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| Essential role of the molecular chaperone gp96 in regulating melanogenesis.
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| Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z.
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| Pigment Cell Melanoma Res 27(1):82-9. doi: 10.1111/pcmr.12165. Epub 2013 Oct 9.
2014
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| 8 | HSP90AA1, HSP90B1, KCNQ4
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| Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
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| Gao Y, Yechikov S, Vazquez AE, Chen D, Nie L.
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| PLoS One 8(2):e57282. doi: 10.1371/journal.pone.0057282. Epub 2013 Feb 19.
2013
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| 9 | HSP90B1
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| Regulation of the expression of chaperone gp96 in macrophages and dendritic cells.
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| Wolfram L, Fischbeck A, Frey-Wagner I, Wojtal KA, Lang S, Fried M, Vavricka SR, Hausmann M, Rogler G.
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| PLoS One 8(10):e76350. doi: 10.1371/journal.pone.0076350. eCollection 2013.
2013
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| 10 | HSP90B1
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| Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.
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| Luo B, Tseng CC, Adams GB, Lee AS.
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| Stem Cells Dev 22(23):3062-73. doi: 10.1089/scd.2013.0181. Epub 2013 Aug 20.
2013
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| 11 | HSP90B1, TLR9
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| Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.
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| Brooks JC, Sun W, Chiosis G, Leifer CA.
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| Biochem Biophys Res Commun 421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.
2012
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| 12 | HSP90B1
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| Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.
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| Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM.
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| Arthritis Rheum 64(11):3638-48. doi: 10.1002/art.34610.
2012
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| 13 | HSP90B1
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| The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain.
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| Wu S, Hong F, Gewirth D, Guo B, Liu B, Li Z.
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| J Biol Chem 287(9):6735-42. doi: 10.1074/jbc.M111.309526. Epub 2012 Jan 5.
2012
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| 14 | HSP90B1, HSPA5, TLR4
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| Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress.
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| Coope A, Milanski M, Arruda AP, Ignacio-Souza LM, Saad MJ, Anhê GF, Velloso LA.
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| J Biol Chem 287(19):15580-9. doi: 10.1074/jbc.M111.315218. Epub 2012 Mar 16.
2012
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| 15 | CSNK2A1, HSP90B1
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| Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide.
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| Miyata Y, Yoneda Y, Yahara I.
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| Mol Cell Biochem 356(1-2):191-200. doi: 10.1007/s11010-011-0944-9. Epub 2011 Jul 8. 2011
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| 16 | CNPY3, HSP90B1, RNF216, UNC93B1
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| Localisation and trafficking of Toll-like receptors: an important mode of regulation.
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| McGettrick AF, O'Neill LA.
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| Curr Opin Immunol 22(1):20-7. Epub 2010 Jan 7.PMID: 20060278 2010
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| 17 | AIMP1, HSP90B1, MYD88
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| Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation.
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| Kim G, Han JM, Kim S.
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| Biochem Biophys Res Commun 397(1):100-5. Epub 2010 May 16.PMID: 20510162 2010
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| 18 | CNPY3, HSP90B1
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| Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.
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| Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z.
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| Nat Commun 1:79. doi: 10.1038/ncomms1070. Erratum in: Nat Commun. 2012;3. doi:10.1038/ncomms1398.
2010
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| 19 | HSP90B1
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| An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.
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| Ostrovsky O, Makarewich CA, Snapp EL, Argon Y.
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| Proc Natl Acad Sci U S A 106(28):11600-5. Epub 2009 Jun 24.
2009
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| 20 | CNPY3, HSP90B1
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| Chaperones and transport proteins regulate TLR4 trafficking and activation.
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| Saitoh SI.
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| Immunobiology mmunobiology. 2009 Feb 26. [Epub ahead of print]PMID: 19250701 2009
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| 21 | HSP90B1, OS9, SEL1L
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| OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
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| Christianson JC, Shaler TA, Tyler RE, Kopito RR.
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| Nat Cell Biol 10(3):272-82. Epub 2008 Feb 10.
2008
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| 22 | HSP90B1
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| Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.
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| Liu B, Li Z.
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| Blood 112(4):1223-30. Epub 2008 May 28.PMID: 18509083 2008
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| 23 | HSP90B1
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| Association analysis of HSP90B1 with bipolar disorder.
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| Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T.
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| J Hum Genet 52(10):794-803. Epub 2007 Sep 4. 2007
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| 24 | HSP90B1, ICMT
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| Inhibition of ICMT induces endothelial cell apoptosis through GRP94.
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| Lu Q, Harrington EO, Newton J, Jankowich M, Rounds S.
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| Am J Respir Cell Mol Biol 37(1):20-30. Epub 2007 Mar 8.
2007
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| 25 | HSP90B1
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| The peptide-binding activity of GRP94 is regulated by calcium.
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| Biswas C, Ostrovsky O, Makarewich CA, Wanderling S, Gidalevitz T, Argon Y.
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| Biochem J 405(2):233-41.
2007
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| 26 | HSP90B1
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| GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
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| Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y.
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| Mol Biol Cell 18(10):3764-75. Epub 2007 Jul 18.
2007
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| 27 | HSP90B1
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| The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells.
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| Biswas C, Sriram U, Ciric B, Ostrovsky O, Gallucci S, Argon Y.
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| Int Immunol 18(7):1147-57. Epub 2006 Jun 13. 2006
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| 28 | HSP90AA1, HSP90AA2, HSP90AA3P, HSP90AA4P, HSP90AA5P, HSP90AA6P, HSP90AB1, HSP90AB2P, HSP90AB3P, HSP90AB5P, HSP90AB6P, HSP90B1, HSP90B2P, HSP90B3P, TRAP1
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| The HSP90 family of genes in the human genome: insights into their divergence and evolution.
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| Chen B, Piel WH, Gui L, Bruford E, Monteiro A.
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| Genomics 86(6):627-37. Epub 2005 Nov 2. 2005
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| 29 | HSP90B1
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| Structure of unliganded GRP94, the endoplasmic reticulum Hsp90. Basis for nucleotide-induced conformational change.
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| Dollins DE, Immormino RM, Gewirth DT.
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| J Biol Chem 280(34):30438-47. Epub 2005 Jun 11. 2005
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| 30 | ADGRG1, ALG5, APLP2, B3GNT3, BGN, C14orf1, CD151, CD99, CDH1, CDH32, CLPTM1, CNPY3, DAG1, DHX8, FXYD5, GDF15, HSP90B1, HSPA5, KRTCAP2, LAMA3, LMAN2, LYPD3, SPINT2, TEX261, TNFRSF12A
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| Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.
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| Bonkobara M, Das A, Takao J, Cruz PD, Ariizumi K.
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| Br J Dermatol 148(4):654-64. 2003
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| 31 | HSPA9, HSP90B1
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| Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94.
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| Takano S, Wadhwa R, Mitsui Y, Kaul SC.
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| Biochem J 357(Pt 2):393-8. 2001
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| 32 | ASCL1, HSP90B1
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| Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23.
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| Renault B, et al.
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| Genomics 30 : 81-83. 1995
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| 33 | HSP90B1, TRAP1, HSP90B3P
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| Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.
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| Maki RG, et al.
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| Somat Cell Mol Genet 19 : 79-81. 1993
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