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FLASH GENE
Symbol HPGD contributors: mct/npt - updated : 15-07-2008
HGNC name hydroxyprostaglandin dehydrogenase 15-(NAD)
HGNC id 5154
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Hpgd
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catabolic enzyme controling the biological activities of prostaglandins by converting them into inactive keto-metabolites
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CRHR1 and CRHR2 (mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    ANIMAL & CELL MODELS