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FLASH GENE
Symbol HPGD contributors: mct/npt - updated : 15-07-2008
HGNC name hydroxyprostaglandin dehydrogenase 15-(NAD)
HGNC id 5154
Corresponding disease
ICNC isolated congenital nail clubbing
PHTO primary hypertrophic osteoarthropathy
Location 4q34.1      Physical location : 175.411.327 - 175.444.044
Synonym name
  • NAD+ dependent 15-hydroxyprostaglandin dehydrogenase
  • prostaglandin dehydrogenase 1
    • Synonym symbol(s) PGDH1,15-PGDH, PGDH
    EC.number 1.1.1.141
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 32.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • distal promoter element PGDH-DE (positions-2152/-1944 relative to the start codon) contains binding sites for Ets and activating protein-1 (AP-1) flanked by two cAMP-responsive element-binding protein binding sites (CREB1, CREB2),
  • proximal element PGDH-PE (-235/-153) includes an Ets and an AP-1 binding sequence
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2592 28.9 266 - Uppal (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
     female systemuterus  highly
    Respiratorylung   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Hpgd
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catabolic enzyme controling the biological activities of prostaglandins by converting them into inactive keto-metabolites
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CRHR1 and CRHR2 (mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    corresponding disease(s) PHTO , ICNC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    notably in colorectal cancer and non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene HPGD mutation analysis and/or urinary PGE2 and PGE-M measurements may prove to be useful early investigations in patients with unexplained clubbing
    Marker
    Therapy target
    ANIMAL & CELL MODELS