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FLASH GENE
Symbol CXCL9 contributors: mct - updated : 04-10-2013
HGNC name chemokine (C-X-C motif) ligand 9
HGNC id 7098
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
small inducible cytokine
HOMOLOGY
Homologene
FAMILY
  • intercrine alpha (chemokine CxC) family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • T cells and NK cells chemoattractant
  • affecting the growth, movement, or activation state of cells that participate in immune and inflammatory response
  • roles in both host defense of the male urogenital tract and during fertilization
  • participate in immune and inflammatory responses through the chemoattraction and activation of polymorphonuclear neutrophils, T cells and B cells
  • promotes CXCR3-dependent immune-mediated kidney disease
  • recruit donor-reactive T cells to the allograft, and promotes the development of IFN-gamma-producing CD8 T cells
  • has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL9-CXCR3 regulates Th1-associated immune pathways in liver
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the receptor CXCR3, which also binds two other structurally related ligands: IFN-gamma-inducible protein CXCL10, CXCL11
  • CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2
    • cell & other
    REGULATION
    induced by interferon gamma inducible
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in colonic tissues of Crohn's disease (CD) and ulcerative colitis (UC)
    Susceptibility
  • to Crohn disease (CD) and ulcerative colitis (UC)
    • Variant & Polymorphism SNP increasing the risk of Crohn disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS