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FLASH GENE
Symbol PTPRM contributors: - updated : 12-04-2006
HGNC name protein tyrosine phosphatase, receptor type, M
HGNC id 9675
Location 18p11.2      Physical location : 7.567.313 - 8.406.858
Synonym symbol(s) PTPRL1, R-PTP-MU, RPTPM, RPTPU
EC.number 3.1.3.48
DNA
TYPE like-sequence
STRUCTURE 839.00 kb     31 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunethymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular region
  • a single transmembrane region
  • and two tandem catalytic domains
  • four 4 fibronectin type-III domains
  • a Ig-like c2-type (immunoglobulin-like) domain
  • a MAM domain
  • two tyrosine-protein phosphatase domains
    • HOMOLOGY
    Homologene
    FAMILY protein tyrosine phosphatase (PTP) family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION may play a key role in signal transduction and growth control
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS