| Symbol
| CD14
| contributors: shn/mct - updated : 07-04-2020
|
| HGNC name
| CD14 molecule
|
| HGNC id
| 1628
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
|
in preterm infants with Early-onset sepsis (EOS) compared with uninfected infants  | | tumoral
|
|
| --other
|
| |
dysfunction in the CD14/TLR4 antagonism may contribute to normal epithelial transition to colonic carcinogenesis | |
| Susceptibility
|
severe chronic periodontitis to Crohn disease (in association with CARD15) to IgA nephropathy in progression to laryngeal cancer to non-alcoholic fatty liver disease (NAFLD) |
| Variant & Polymorphism
| 159 TT allele and1359G:/T increases this risk of Crohn disease |
|
T159C associated to IgA nephropathy in progression |
|
genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer |
|
CD14 C (-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development |
| 
|
Candidate gene
| Marker
| presepsin could be a useful biomarker for the early diagnosis of sepsis, also for pediatric sepsis | |
plasma soluble CD14 level might be a potential biomarker in prediction of asthma severity in adults | |
presepsin could be a useful biomarker of sepsis secondary to fungal infections | |
is a valuable biomarker to detect patients with acute pyelonephritis | Therapy target
|
| | |
|
| CD14-deficient miceare highly resistant to shock induced by either live Gram-negative bacteria or LPS and show dramatically reduced levels of bacteremia | |
Bone marrow-derived macrophages (BMDMs) from CD14-/- mice exhibited impaired responses to polyinosine-polycytidylic acid (pIpC) and reduced production of inflammatory cytokines |
|
mice lacking CD14 exhibited reduced insoluble, but not soluble, levels of betta-amyloid at 7 months of age and have a significant change in the inflammatory environment of the brain |