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FLASH GENE
Symbol CD14 contributors: shn/mct - updated : 07-04-2020
HGNC name CD14 molecule
HGNC id 1628
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in preterm infants with Early-onset sepsis (EOS) compared with uninfected infants
tumoral     --other  
dysfunction in the CD14/TLR4 antagonism may contribute to normal epithelial transition to colonic carcinogenesis
Susceptibility
  • severe chronic periodontitis
  • to Crohn disease (in association with CARD15)
  • to IgA nephropathy in progression
  • to laryngeal cancer
  • to non-alcoholic fatty liver disease (NAFLD)
    • Variant & Polymorphism
  • 159 TT allele and1359G:/T increases this risk of Crohn disease
  • T159C associated to IgA nephropathy in progression
  • genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer
  • CD14 C (-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development
    • Candidate gene
    Marker
  • presepsin could be a useful biomarker for the early diagnosis of sepsis, also for pediatric sepsis
  • plasma soluble CD14 level might be a potential biomarker in prediction of asthma severity in adults
  • presepsin could be a useful biomarker of sepsis secondary to fungal infections
  • is a valuable biomarker to detect patients with acute pyelonephritis
    • Therapy target
    ANIMAL & CELL MODELS
  • CD14-deficient miceare highly resistant to shock induced by either live Gram-negative bacteria or LPS and show dramatically reduced levels of bacteremia
  • Bone marrow-derived macrophages (BMDMs) from CD14-/- mice exhibited impaired responses to polyinosine-polycytidylic acid (pIpC) and reduced production of inflammatory cytokines
  • mice lacking CD14 exhibited reduced insoluble, but not soluble, levels of betta-amyloid at 7 months of age and have a significant change in the inflammatory environment of the brain