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FLASH GENE

Symbol

UBE2B

contributors: mct/npt/pgu - updated : 09-11-2015

HGNC name	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
HGNC id	12473

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in oligozoospermic patients tumoral     --over   in breast cancer and induces CTNNB1 transcriptional activation and stabilization via K63-linked polyubiquitination

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	absence of Ube2b in male mice causes spermatogenic meiotic disruption with increased apoptosis, leading to infertility
	loss of Rnf8 or Ube2b can lead to sterility in male mice