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FLASH GENE
Symbol UBE2B contributors: mct/npt/pgu - updated : 09-11-2015
HGNC name ubiquitin-conjugating enzyme E2B (RAD6 homolog)
HGNC id 12473
Location 5q31.1      Physical location : 133.706.869 - 133.727.798
Synonym name
  • E2 protein
  • ubiquitin-protein ligase B
  • ubiquitin carrier protein B
  • E2-17 kDa
    • Synonym symbol(s) D5S1636E, UBC2, RAD6B, E2-17kDa, E2-17kDa, HHR6B, HR6B
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 20.93 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a CGG repeat in 5'utr
    MAPPING cloned Y linked N status confirmed
    Map cen - C5orf15 - TCF7 - UBE2B - PHF15 - C5orf24 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2631 - 152 - 1996 8575614
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
    • HOMOLOGY
    interspecies homolog to yeast RAD6,B
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ubiquitin conjugating enzyme E2B, involved in post replication repair
  • have a specific role in spermatogenesis, involving ubiquitin -mediated histone degradation
  • transcriptional target of beta-catenin, and the positive regulatory feedback loop between UBE2B and beta-catenin is linked to a novel mechanism of beta-catenin stabilization/activation in breast cancer cells
  • represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids
  • intrinsically capable of catalyzing ubiquitin chain formation
  • RAD18 and UBE2B have a role in the efficient repair of a small subset of meiotic DSBs
  • plays a critical role in regulating TP53 protein levels under both normal and stress conditions
  • UBE2A, UBE2B regulates TP53 levels in a "yin-yang" manner through a combination of two distinct mechanisms in mammalian cells
  • involved in the regular and symmetric organization of the fibrous sheath of sperm flagella
    • CELLULAR PROCESS cell cycle
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RAD18 complexed with UBE2B protein preferentially binds to forked and single-stranded DNA (ssDNA) structures, which are known to be localized at stalled replication forks
  • RNF168, in complex with UBE2A or UBE2B, is activated in the DNA-damage-induced protein ubiquitination cascade
  • UBE2A, UBE2B can form a ternary complex with MDM2 and TP53 that contributes to the degradation of TP53
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2A, RAD18
  • transcriptional target of beta-catenin/TCF
  • interacting with UBR2 (interacts with UBE2B and its substrate HIST2H2AC and promotes the UBE2B–HIST2H2AC interaction and the UBE2B-to-HIST2H2AC transfer of ubiquitin)
  • RNF168, in complex with UBE2A or UBE2B, is activated in the DNA-damage-induced protein ubiquitination cascade
  • UBE2B is a direct AR transcriptional target in Sertoli cells, mediates the function of AR in spermatogenesis by promoting H2A ubiquitylation
  • interplay between UBE2A, UBE2B and ASF1A associates with tumorigenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in oligozoospermic patients
    tumoral     --over  
    in breast cancer and induces CTNNB1 transcriptional activation and stabilization via K63-linked polyubiquitination
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • absence of Ube2b in male mice causes spermatogenic meiotic disruption with increased apoptosis, leading to infertility
  • loss of Rnf8 or Ube2b can lead to sterility in male mice