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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

IL11

contributors: mct/pgu - updated : 03-01-2012

HGNC name	interleukin 11
HGNC id	5966

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   with HGF, in polycythemia vera (PV) constitutional     --over   in retina and cornea cells constitutional     --over   enhances canonical Wnt signal at least in part via a reduction in DKK2 expression to stimulate osteoblast differentiation tumoral     --over   in the endometrial tumour epithelial cells from Grade 1 and 3

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	IL11 in uterine washings may be useful as a diagnostic marker for early stage endometrial cancer
Therapy target
	System Type Disorder Pubmed osteoarticular bone   possibility of modulation of IL11 signaling for the treatment of craniosynostosis cancer hemopathy   blocking the MET/HGF/IL11 pathways could be of interest as an additional therapeutic option in polycythemia vera immunology autoimmune multiple sclerosis IL-11 signaling may represent a therapeutic avenue to restrict CNS inflammation and potentiate oligodendrocyte survival in autoimmune demyelinating disease

ANIMAL & CELL MODELS