SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,cytosolic,vesicle
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| highly expressed in the sarcoplasmic reticulum (SR) where it colocalizes with the ryanodine receptor and DMPK |
basic FUNCTION
| regulating the activity of the sarcoplasmic Ca++ ATPase (ATP2A2) isoform a, regulator of the kinetics of cardiac contraction (diastolic function) |
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phosphorylation of PLN acts to release constraints involving interdomain subunit interactions that enhance catalytically important N-domain motions |
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enriched in the ER due to COP I-mediated transport that is dependent on its intact di-arginine motif and the N-terminal di-arginine motif may act as a general ER retrieval sequence |
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unphosphorylated PLN reduces ATP2A1 affinity for Ca(2+) and affects the enzymatic turnover |
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crucial Ca(2+) cycling protein and a primary mediator of the beta-adrenergic effects resulting in enhanced cardiac output |
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inhibitor of cardiac sarco(endo)plasmic reticulum Ca²& |
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8314; ATPase |
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effect of PLN and SLN, which becomes synergic when they are both present in the SR membrane, is expected to favor a rapid equilibration of ions on both sides of the membrane |
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PLN does not function as a simple on/off switch for Ca2+ translocation; rather, its conformational equilibrium exerts a gradual control (“physiological rheostat”) on ATP2A1 activity |
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SLN and its close analog phospholamban (PLN) are membrane proteins that regulate SERCA by inhibiting Ca(2+) transport in skeletal and cardiac muscl |
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SLN, not PLN, is required for muscle-based thermogenesis |