| 1 | HAX1, PLN
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| The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart
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| Bidwell PA, Haghighi K, Kranias EG.
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| J Biol Chem. Jan 5;293(1):359-367. doi: 10.1074/jbc.RA117.000128. Epub 2017 Nov 17. 2018
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| 2 | PLN, SLN
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| Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
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| Shaikh SA, Sahoo SK, Periasamy M.
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| J Mol Cell Cardiol 91:81-91. doi: 10.1016/j.yjmcc.2015.12.030. Epub 2015 Dec 29. Review.
2016
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| 3 | LMOD1, PDLIM7, PLN, SYNM, SYNPO2
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| Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. 2016 PMID:
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| Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojević V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous T, Hamsten A, Hedin U.
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| Arterioscler Thromb Vasc Biol. Sep;36(9):1947-61. doi: 10.1161/ATVBAHA.116.307893. Epub 2016 Jul 28. 2016
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| 4 | ATP2A1, PLN, SLN
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| Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
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| Espinoza-Fonseca LM, Autry JM, Thomas DD.
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| Biochem Biophys Res Commun 463(1-2):37-41. doi: 10.1016/j.bbrc.2015.05.012. Epub 2015 May 15.
2015
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| 5 | ATP2A1, PLN
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| Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban.
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| Gustavsson M, Verardi R, Mullen DG, Mote KR, Traaseth NJ, Gopinath T, Veglia G.
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| Proc Natl Acad Sci U S A 110(43):17338-43. doi: 10.1073/pnas.1303006110. Epub 2013 Oct 7.
2013
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| 6 | CMD1P, PLN
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| Arrhythmogenic right ventricular dysplasia/cardiomyopathy according to revised 2010 task force criteria with inclusion of non-desmosomal phospholamban mutation carriers.
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| Groeneweg JA, van der Zwaag PA, Olde Nordkamp LR, Bikker H, Jongbloed JD, Jongbloed R, Wiesfeld AC, Cox MG, van der Heijden JF, Atsma DE, de Boer K, Doevendans PA, Vink A, van Veen TA, Dooijes D, van den Berg MP, Wilde AA, van Tintelen JP, Hauer RN.
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| Am J Cardiol 112(8):1197-206. doi: 10.1016/j.amjcard.2013.06.017. Epub 2013 Jul 19.
2013
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| 7 | PLN
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| Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.
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| Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.
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| Circ Res 113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.
2013
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| 8 | ATP2A1, PLN
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| Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity.
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| Smeazzetto S, Saponaro A, Young HS, Moncelli MR, Thiel G.
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| PLoS One 8(1):e52744. doi: 10.1371/journal.pone.0052744. Epub 2013 Jan 4.
2013
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| 9 | PLN, SLN
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| Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
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| Fajardo VA, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, Gramolini AO, Quadrilatero J, Tupling AR.
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| PLoS One 8(12):e84304. doi: 10.1371/journal.pone.0084304. eCollection 2013.
2013
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| 10 | PLN, SLN
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| Can proton pumping by SERCA enhance the regulatory role of phospholamban and sarcolipin?
|
| Becucci L, Foresti ML, Schwan A, Guidelli R.
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| Biochim Biophys Acta 1828(11):2682-90. doi: 10.1016/j.bbamem.2013.07.012. Epub 2013 Jul 18.
2013
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| 11 | CMD1P, PLN
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| Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy.
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| van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP.
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| Eur J Heart Fail 14(11):1199-207. doi: 10.1093/eurjhf/hfs119. Epub 2012 Jul 20.
2012
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| 12 | ATP2A1, PLN
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| Activating and deactivating roles of lipid bilayers on the Ca(2+)-ATPase/phospholamban complex.
|
| Gustavsson M, Traaseth NJ, Veglia G.
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| Biochemistry 50(47):10367-74. doi: 10.1021/bi200759y. Epub 2011 Nov 8.
2011
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| 13 | PLN
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| Mutations in the human phospholamban gene in patients with heart failure.
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| Medeiros A, Biagi DG, Sobreira TJ, de Oliveira PS, Negrão CE, Mansur AJ, Krieger JE, Brum PC, Pereira AC.
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| Am Heart J 162(6):1088-1095.e1. doi: 10.1016/j.ahj.2011.07.028. Epub 2011 Nov 8.
2011
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| 14 | ATP2A1, PLN
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| Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump.
|
| Glaves JP, Trieber CA, Ceholski DK, Stokes DL, Young HS.
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| J Mol Biol 405(3):707-23. doi: 10.1016/j.jmb.2010.11.014. Epub 2010 Nov 23.
2011
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| 15 | PLN, SLN
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| Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.
|
| Shanmugam M, Gao S, Hong C, Fefelova N, Nowycky MC, Xie LH, Periasamy M, Babu GJ.
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| Cardiovasc Res 89(2):353-61. doi: 10.1093/cvr/cvq294. Epub 2010 Sep 10.
2011
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| 16 | PLN
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| Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?
|
| Sharma P, Ignatchenko V, Grace K, Ursprung C, Kislinger T, Gramolini AO.
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| PLoS One 5(7):e11496. doi: 10.1371/journal.pone.0011496.
2010
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| 17 | ATP2A2, PLN
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| Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
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| Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ.
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| Circulation 119(3):436-44. Epub 2009 Jan 12.
2009
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| 18 | PLN
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| Phospholamban modulates the functional coupling between nucleotide domains in Ca-ATPase oligomeric complexes in cardiac sarcoplasmic reticulum.
|
| Chen LT, Yao Q, Soares TA, Squier TC, Bigelow DJ.
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| Biochemistry 48(11):2411-21. doi: 10.1021/bi8021526.
2009
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| 19 | PLN, CMD1P
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| A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.
|
| Haghighi K, Chen G, Sato Y, Fan GC, He S, Kolokathis F, Pater L, Paraskevaidis I, Jones WK, Dorn GW 2nd, Kremastinos DT, Kranias EG.
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| Hum Mutat 29(5):640-7. 2008
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| 20 | ATP2A2, PLN, SLN
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| SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects.
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| Vittorini S, Storti S, Parri MS, Cerillo AG, Clerico A.
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| Mol Med 13(1-2):105-11.
2007
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| 21 | CALR3, CASQ2, PLN
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| Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy.
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| Chiu C, Tebo M, Ingles J, Yeates L, Arthur JW, Lind JM, Semsarian C.
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| J Mol Cell Cardiol 43(3):337-43. Epub 2007 Jun 30.PMID: 17655857 2007
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| 22 | PLN, CMD1P
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| A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
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| Haghighi K, Kolokathis F, Gramolini AO, Waggoner JR, Pater L, Lynch RA, Fan GC, Tsiapras D, Parekh RR, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG.
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| Proc Natl Acad Sci U S A 103(5):1388-93. Epub 2006 Jan 23. 2006
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| 23 | DMPK, PLN
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| Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
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| Kaliman P, Catalucci D, Lam JT, Kondo R, Gutierrez JC, Reddy S, Palacin M, Zorzano A, Chien KR, Ruiz-Lozano P.
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| J Biol Chem 280(9):8016-21. Epub 2004 Dec 13. 2005
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| 24 | MYH6, PLN, CMH6, CMD1W
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| Molecular genetics and genomics of heart failure.
|
| Liew CC, Dzau VJ.
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| Nat Rev Genet 5(11):811-25. 2004
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| 25 | PLN
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| Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy.
|
| Minamisawa S, Sato Y, Tatsuguchi Y, Fujino T, Imamura S, Uetsuka Y, Nakazawa M, Matsuoka R.
|
| Biochem Biophys Res Commun 304(1):1-4. 2003
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| 26 | CMD1P, CMD1R, PLN
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| Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.
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| Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE.
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| Science 299(5611):1410-3. 2003
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| 27 | PLN
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| The human phospholamban gene: structure and expression.
|
| McTiernan CF, et al.
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| J Mol Cell Cardiol 31(3):679-92. 1999
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| 28 | ATP2A2, PLN
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| Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
|
| Minamisawa S, et al.
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| Cell 99(3):313-22 1999
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| 29 | PLN
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| Phospholamban: a protein coming of age.
|
| Kadambi VJ, Kranias EG.
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| Biochem Biophys Res Commun 239(1):1-5. 1997
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| 30 | ATP2A2, PLN, CASQ1, CASQ2, RYR2
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| Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.
|
| Otsu K, et al.
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| Genomics 17 : 507-509. 1993
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| 31 | PLN
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| Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.
|
| Fujii J, et al.
|
| J Biol Chem 266 : 11669-11675. 1991
|