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FLASH GENE
Symbol IL6ST contributors: mct/ - updated : 13-09-2017
HGNC name interleukin 6 signal transducer (gp130, oncostatin M receptor)
HGNC id 6021
Location 5q11.2      Physical location : 55.230.937 - 55.290.821
Synonym name
  • oncostatin M receptor
  • gp130 transducer chain
  • interleukin receptor beta chain
  • membrane glycoprotein gp130
  • IL-6 receptor subunit beta2
  • CD130 antigen
  • Synonym symbol(s) GP130, IL6ST1, CD130, CDw130, IL6R-beta, DKFZp564F053
    DNA
    TYPE functioning gene
    STRUCTURE 59.90 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29 PPAP2A 5q11 phosphatidic acid phosphatase type 2A LOC379013  ring finger protein 138 pseudogene LOC391785 5 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) FLJ90709 5q11.2 hypothetical protein FLJ90709 DDX4 5q11.2-q12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 LOC391786 5 similar to heterogeneous nuclear ribonucleoprotein H CRL3 5q11.2 gp130-like monocyte receptor IL6ST 5q11.1-q11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) FLJ11795 5q11.2 hypothetical protein FLJ11795 LOC345645 5q11.2 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC347593 5q11.2 60S ribosomal protein L26 pseudogene MAP3K1 5q11.2 mitogen-activated protein kinase kinase kinase 1 MGC33648 5q11.2 hypothetical protein MGC33648 FLJ35954 5q11.2 hypothetical protein FLJ35954 DKFZp761C169 5q11.2 vasculin LOC133374 5q11.2 similar to hypothetical protein FLJ10534 LOC391787 5 similar to sal-like 4 LOC345651 5q12.1 similar to RIKEN cDNA 4732495G21 gene SNK 5q12.1-q13.2 serum-inducible kinase FLJ33641 5q12.1 hypothetical protein FLJ33641 RAB3C 5q13 RAB3C, member RAS oncogene family
    RNA
    TRANSCRIPTS type messenger
    text with an alternatively spliced secreted form
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 9071 - 918 - 2007 17436251
    16 - 8988 - 329 - 2007 17436251
    16 - 8888 - 857 - 2000 10675624
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytokine binding domain (CBD)
  • two fibronectin III domains linked by a proline-rich sequence: N-terminal fibronectin III domain of the CBD characterized by two conserved disulfide bridges
  • C-terminal fibronectin III domain of the CBD with a conserved WSXWS motif
  • intracellula
  • N-glycosylation of the extracellular domains D1-D3 has been shown to be dispensable for binding of the IL6ST ligand IL-6 and its cognate receptor
  • box 1 and box 2-like motifs conserved in cytokine receptors
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class I hematopoietin receptor family
  • CATEGORY signaling hormone cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein, cholesterol enriched membrane microdomains (rafts)
    basic FUNCTION
  • interleukin 6, signal transducer (GP130), needed for IL6R activity and signal transduction of the IL-6 related cytokines mediated by JAK kinases
  • IL6 and IL6ST may enhance pain not only indirectly through their proinflammatory actions but also through a direct action on nociceptors
  • its activation in photoreceptors had potentially a general protective role independent of whether stress was caused by light or genetic mutations
  • shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • common transducing component for IL6RA, LIFR, CNTFR, CSF3R (see symbols)
  • component of microdomains rafts
  • heterodimerizing with OSMR
  • quaternary cytokine receptor complex consisting of IL6ST, LIFR, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTFRA)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • shared receptor for at least nine cytokines and can signal either as a homodimer or as a heterodimer with Leukemia Inhibitory Factor Receptor (LIFR)
  • MTRNR2L1 inhibits neuronal cell death and dysfunction by binding to a novel IL6-receptor-related receptor(s) on the cell surface involving CNTFR, IL27RA, and IL6ST
  • interacting with Sortilin
  • TRAF5 binds to the signal-transducing receptor IL6ST through the C-terminal TRAF domain and inhibits Th17 development mediated by IL6
  • cell & other
    REGULATION
    Other regulated by N-linked glycosylation that is required for the stability but not the signal-transducing function
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS