Citations for
1CNTF, IL6ST, SORT1
Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.
Larsen JV, Hansen M, Mřller B, Madsen P, Scheller J, Nielsen M, Petersen CM.
Mol Cell Biol 30(17):4175-87. Epub 2010 Jun 28. 2010
2IL6ST
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J.
Mol Biol Cell 21(15):2797-807. Epub 2010 Jun 16.PMID: 20554759 2010
3IL6ST
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
Xu Y, Kershaw NJ, Luo CS, Soo P, Pocock MJ, Czabotar PE, Hilton DJ, Nicola NA, Garrett TP, Zhang JG.
J Biol Chem 285(28):21214-8. Epub 2010 May 20.PMID: 20489211 2010
4IL6ST
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D.
J Biol Chem 285(3):1781-9. Epub 2009 Nov 13.PMID: 19915009 2010
5CNTFR, IL6ST, MTRNR2L1
Humanin and the receptors for humanin.
Matsuoka M, Hashimoto Y.
Mol Neurobiol 41(1):22-8. Epub 2009 Dec 9. Review. 2010
6CNTFR, IL27RA, IL6ST
Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.
Hashimoto Y, Kurita M, Matsuoka M.
Biochem Biophys Res Commun 389(1):95-9. Epub 2009 Aug 22. 2009
7IL6ST
Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors.
Ueki Y, Le YZ, Chollangi S, Muller W, Ash JD.
Proc Natl Acad Sci U S A 106(50):21389-94. Epub 2009 Nov 30.PMID: 19948961 2009
8IL6, IL6ST
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M.
J Neurosci 29(43):13473-83.PMID: 19864560 2009
9IL6ST
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR.
Cancer Cell 15(2):91-102.PMID: 19185844 2009
10CLCF1, CNTF, CNTFR, CTF2P, IL6ST
Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.
Rousseau F, Chevalier S, Guillet C, Ravon E, Diveu C, Froger J, Barbier F, Grimaud L, Gascan H.
J Biol Chem 283(44):30341-50. Epub 2008 Aug 26. 2008
11CBL, IL6ST
c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.
Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K.
Mol Cell Biol 28(15):4805-18. Epub 2008 Jun 2.PMID: 18519587 2008
12CNTF, CNTFR, IL6ST, LIFR
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC.
Mol Cell 31(5):737-48. 2008
13CISS1, CRLF1, IL6ST, LIFR, MCTHS
Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.
Dagoneau N, Bellais S, Blanchet P, Sarda P, Al-Gazali LI, Di Rocco M, Huber C, Djouadi F, Le Goff C, Munnich A, Cormier-Daire V.
Am J Hum Genet 80(5):966-70. Epub 2007 Mar 13. 2007
14IL6ST, LIFR
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells.
Giese B, Roderburg C, Sommerauer M, Wortmann SB, Metz S, Heinrich PC, Muller-Newen G.
J Cell Sci 118(Pt 21):5129-40. 2005
15IL27RA, IL6ST
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.
Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.
J Immunol 172(4):2225-31. 2004
16CTF1, IL6ST
Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance.
Zolk O, Ng LL, O'Brien RJ, Weyand M, Eschenhagen T.
Circulation 106(12):1442-6. 2002
17IL6ST
Exon-intron organization of the human gp130 gene.
Szalai C, Toth S, Falus A.
Gene 243(1-2):161-6. 2000
18IL6ST, STAT3
STAT3 orchestrates contradictory signals in cytokine-induced G 1 to S cell-cycle transition.
Fukada T, et al.
EMBO J 17 : 6670-6677. 1998
19IL6ST, STAT3
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.
J Immunol 161(9):4652-60 1998
20IL6ST
Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130.
Diamant M, Rieneck K, Mechti N, Zhang XG, Svenson M, Bendtzen K, Klein B.
FEBS Lett 412(2):379-84. 1997
21IL6ST, IL6STP
Human gp 130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11.
Rodriguez C, et al.
Cytogenet Cell Genet 70 : 64-67. 1995
22IL6ST, IL6STP
Chromosomal localization of the IL-6 receptor signal transducing subunit, gp130 (IL6ST).
Kidd VJ, et al.
Somat Cell Mol Genet 18 : 477-483. 1992
23IL6ST
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T.
Proc Natl Acad Sci U S A 88(24):11349-53. 1991
24IL6ST, IL6STP
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Hibi M, et al.
Cell 63(6):1149-57. 1990