| Symbol
| PIM1
| contributors: mct/pgu - updated : 10-10-2016
|
| HGNC name
| pim-1 oncogene
|
| HGNC id
| 8986
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
| |
in Burkitt's lymphoma | | tumoral
|
|
| --over
|
| |
upregulated by the Kaposi sarcoma-associated herpes virus in infected B cells | | tumoral
|
|
| --over
|
|
protein kinase up-regulated in prostate cancer  | | tumoral
|
|
| --over
|
| |
up-regulation of PIM1 might be a tumor marker for gastric cancer | | tumoral
|
|
| --over
|
| |
prognostic marker in pancreatic ductal adenocarcinoma | | tumoral
|
|
| --low
|
| |
significant association between PIM1 down-regulation and occurence of lymph node metastases in non-small cell lung cancer | | constitutional
|
|
|
| loss of function
| |
induces a strong adhesive phenotype by enhancing endothelial cell-cell and cell-matrix adhesion by the deposition of a specific extracellular matrix | |
Variant & Polymorphism
| 
| |
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | head and neck | | |
| may be used as a novel predictive marker of radiation response in patients with squamocellular cancers of head and neck | | cancer | hemopathy | | |
| PIM1 specific kinase inhibitors may be promising therapies for BCL6/PIM1-associated lymphomas | | immunology | autoimmune | | |
| could be a new potential therapeutic target in the prevention and treatment of human-specific autoimmune diseases because of its ability to modulate the immunosuppressive activity of human Tregs |
| | | |
|
| compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes |