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FLASH GENE

Symbol

PIM1

contributors: mct/pgu - updated : 10-10-2016

HGNC name	pim-1 oncogene
HGNC id	8986

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in Burkitt's lymphoma tumoral     --over   upregulated by the Kaposi sarcoma-associated herpes virus in infected B cells tumoral     --over   protein kinase up-regulated in prostate cancer tumoral     --over   up-regulation of PIM1 might be a tumor marker for gastric cancer tumoral     --over   prognostic marker in pancreatic ductal adenocarcinoma tumoral     --low   significant association between PIM1 down-regulation and occurence of lymph node metastases in non-small cell lung cancer constitutional       loss of function induces a strong adhesive phenotype by enhancing endothelial cell-cell and cell-matrix adhesion by the deposition of a specific extracellular matrix

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer head and neck   may be used as a novel predictive marker of radiation response in patients with squamocellular cancers of head and neck cancer hemopathy   PIM1 specific kinase inhibitors may be promising therapies for BCL6/PIM1-associated lymphomas immunology autoimmune   could be a new potential therapeutic target in the prevention and treatment of human-specific autoimmune diseases because of its ability to modulate the immunosuppressive activity of human Tregs

ANIMAL & CELL MODELS

compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes