| 1 | FOXP3, PIM1
|
| PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation.
|
| Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B.
|
| J Biol Chem 289(39):26872-81. doi: 10.1074/jbc.M114.586651. Epub 2014 Aug 5.
2014
|
| 2 | MET, PIM1
|
| The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
|
| Cen B, Xiong Y, Song JH, Mahajan S, DuPont R, McEachern K, DeAngelo DJ, Cortes JE, Minden MD, Ebens A, Mims A, LaRue AC, Kraft AS.
|
| Mol Cell Biol 34(13):2517-32. doi: 10.1128/MCB.00147-14. Epub 2014 Apr 28.
2014
|
| 3 | PIM1, PIM2, PIM3
|
| The PIM family of serine/threonine kinases in cancer.
|
| Narlik-Grassow M, Blanco-Aparicio C, Carnero A.
|
| Med Res Rev 34(1):136-59. doi: 10.1002/med.21284. Epub 2013 Apr 10. Review.
2014
|
| 4 | DNM1L, PIM1
|
| Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation.
|
| Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA.
|
| Proc Natl Acad Sci U S A 110(15):5969-74. doi: 10.1073/pnas.1213294110. Epub 2013 Mar 25.
2013
|
| 5 | JUND, PIM1
|
| JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.
|
| Ruppert SM, Chehtane M, Zhang G, Hu H, Li X, Khaled AR.
|
| PLoS One 7(2):e32262. doi: 10.1371/journal.pone.0032262. Epub 2012 Feb 23.
2012
|
| 6 | ISCU, NFS1, PIM1
|
| Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.
|
| Song JY, Marszalek J, Craig EA.
|
| Proc Natl Acad Sci U S A 109(26):10370-5. doi: 10.1073/pnas.1206945109. Epub 2012 Jun 11.
2012
|
| 7 | BCL6, PIM1
|
| PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas.
|
| Baron BW, Anastasi J, Hyjek EM, Bies J, Reddy PL, Dong J, Joseph L, Thirman MJ, Wroblewski K, Wolff L, Baron JM.
|
| Proc Natl Acad Sci U S A 109(15):5735-9. doi: 10.1073/pnas.1201168109. Epub 2012 Mar 26.
2012
|
| 8 | PIM1
|
| Inhibition of the Pim1 oncogene results in diminished visual function.
|
| Yin J, Shine L, Raycroft F, Deeti S, Reynolds A, Ackerman KM, Glaviano A, O'Farrell S, O'Leary O, Kilty C, Kennedy C, McLoughlin S, Rice M, Russell E, Higgins DG, Hyde DR, Kennedy BN.
|
| PLoS One 7(12):e52177. doi: 10.1371/journal.pone.0052177. Epub 2012 Dec 26.
2012
|
| 9 | PIM1
|
| Loss of pim1 imposes a hyperadhesive phenotype on endothelial cells.
|
| Walpen T, Peier M, Haas E, Kalus I, Schwaller J, Battegay E, Humar R.
|
| Cell Physiol Biochem 30(4):1083-96. doi: 10.1159/000341484. Epub 2012 Sep 24.
2012
|
| 10 | PIM1
|
| PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression.
|
| Iadevaia V, Caldarola S, Biondini L, Gismondi A, Karlsson S, Dianzani I, Loreni F.
|
| Oncogene 29(40):5490-9. Epub 2010 Jul 19.
2010
|
| 11 | ETV6, FLT3, PIM1
|
| The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation.
|
| Vu HA, Xinh PT, Kano Y, Tokunaga K, Sato Y.
|
| Biochem Biophys Res Commun 383(3):308-13. Epub 2009 Apr 5.
2009
|
| 12 | MAP3K5, PIM1
|
| PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.
|
| Gu JJ, Wang Z, Reeves R, Magnuson NS.
|
| Oncogene 28(48):4261-71. Epub 2009 Sep 14.PMID: 19749799 2009
|
| 13 | PIM1
|
| Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer.
|
| Warnecke-Eberz U, Bollschweiler E, Drebber U, Metzger R, Baldus SE, Hölscher AH, Mönig S.
|
| Anticancer Res 29(11):4451-5.PMID: 20032391 2009
|
| 14 | PIM1
|
| Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.
|
| Peltola K, Hollmen M, Maula SM, Rainio E, Ristamäki R, Luukkaa M, Sandholm J, Sundvall M, Elenius K, Koskinen PJ, Grenman R, Jalkanen S.
|
| Neoplasia 11(7):629-36.PMID: 19568408 2009
|
| 15 | PIM1, PIM3
|
| KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.
|
| Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM.
|
| PLoS Pathog 5(3):e1000324. Epub 2009 Mar 6.PMID: 19266083 2009
|
| 16 | PIM1
|
| Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer.
|
| He HC, Bi XC, Zheng ZW, Dai QS, Han ZD, Liang YX, Ye YK, Zeng GH, Zhu G, Zhong WD.
|
| Med Oncol 26(3):303-8. Epub 2008 Nov 12.PMID: 19003546 2009
|
| 17 | PIM1
|
| Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma.
|
| Reiser-Erkan C, Erkan M, Pan Z, Bekasi S, Giese NA, Streit S, Michalski CW, Friess H, Kleeff J.
|
| Cancer Biol Ther 7(9):1352-9. Epub 2008 Sep 2.PMID: 18708761 2008
|
| 18 | PIM1
|
| Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases.
|
| Warnecke-Eberz U, Bollschweiler E, Drebber U, Pohl A, Baldus SE, Hoelscher AH, Metzger R.
|
| Oncol Rep 20(3):619-24.PMID: 18695914 2008
|
| 19 | IL3, PIM1
|
| IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
|
| Didichenko SA, Spiegl N, Brunner T, Dahinden CA.
|
| Blood 112(10):3949-58. Epub 2008 Sep 2.
2008
|
| 20 | PIM1, PIM2, PIM3
|
| Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
|
| Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N.
|
| Cancer Res 68(13):5076-85. doi: 10.1158/0008-5472.CAN-08-0634.
2008
|
| 21 | PIM1, PIM2
|
| Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
|
| Chen JL, Limnander A, Rothman PB.
|
| Blood 111(3):1677-85. Epub 2007 Nov 27.
2008
|
| 22 | PIM1
|
| Pim-1 induced polyploidy but did not affect megakaryocytic differentiation of K562 cells and CD34+ cells from cord blood.
|
| Jung YJ, Chae HC, Seoh JY, Ryu KH, Park HK, Kim YJ, Woo SY.
|
| Eur J Haematol 78(2):131-8. 2007
|
| 23 | HOXA9, PIM1
|
| Evidence that the Pim1 kinase gene is a direct target of HOXA9.
|
| Hu YL, Passegué E, Fong S, Largman C, Lawrence HJ.
|
| Blood 109(11):4732-8. Epub 2007 Feb 27.PMID: 17327400 2007
|
| 24 | PIM1, PIN1, PPP2R5B
|
| Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.
|
| Ma J, Arnold HK, Lilly MB, Sears RC, Kraft AS.
|
| Oncogene 26(35):5145-53. Epub 2007 Feb 12.
2007
|
| 25 | PIM1, CDC25C
|
| The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.
|
| Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I, Moroy T.
|
| Int J Biochem Cell Biol 38(3):430-43. Epub 2005 Nov 8. 2006
|
| 26 | PIM1,PIM2,PIM3
|
| Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
|
| Macdonald A, Campbell DG, Toth R, McLauchlan H, Hastie CJ, Arthur JS.
|
| BMC Cell Biol 7:1. 2006
|
| 27 | PIM1
|
| KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity.
|
| Bajaj BG, Verma SC, Lan K, Cotter MA, Woodman ZL, Robertson ES.
|
| Virology 351(1):18-28. Epub 2006 Apr 27. 2006
|
| 28 | PIM1
|
| Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity.
|
| Aho TL, Sandholm J, Peltola KJ, Ito Y, Koskinen PJ.
|
| BMC Cell Biol 7:21. 2006
|
| 29 | PIM1
|
| Structure and substrate specificity of the Pim-1 kinase.
|
| Bullock AN, Debreczeni J, Amos AL, Knapp S, Turk BE.
|
| J Biol Chem 280(50):41675-82. Epub 2005 Oct 13. 2005
|
| 30 | PIM1
|
| Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.
|
| Shay KP, Wang Z, Xing PX, McKenzie IF, Magnuson NS.
|
| Mol Cancer Res 3(3):170-81. 2005
|
| 31 | PIM1,RPS19
|
| Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein.
|
| Chiocchetti A, Gibello L, Carando A, Aspesi A, Secco P, Garelli E, Loreni F, Angelini M, Biava A, Dahl N, Dianzani U, Ramenghi U, Santoro C, Dianzani I.
|
| Haematologica 90(11):1453-62. 2005
|
| 32 | PIM1,PIM2,PIM3
|
| Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.
|
| Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J, Berns A.
|
| Mol Cell Biol 24(13):6104-15. 2004
|
| 33 | MDM2, PIM1
|
| Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.
|
| Ionov Y, Le X, Tunquist BJ, Sweetenham J, Sachs T, Ryder J, Johnson T, Lilly MB, Kraft AS.
|
| Anticancer Res 23(1A):167-78. 2003
|
| 34 | PIM1, PIM2, SOCS1
|
| Pim serine/threonine kinases regulate the stability of Socs-1 protein.
|
| Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.
|
| Proc Natl Acad Sci U S A 99(4):2175-80. 2002
|
| 35 | PIM1
|
| The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.
|
| Saris CJM, et al.
|
| EMBO J 10 : 655-664. 1991
|
| 36 | PIM1
|
| Deletion and linkage mapping of eight markers from the proximal short arm of chromosome 6.
|
| Zoghbi HY, Ballantyne CM, O'Brien WE, McCall AE, Kwiatkowski TJ Jr, Ledbetter SA, Beaudet AL.
|
| Genomics 6(2):352-7. 1989
|
| 37 | PIM1
|
| Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity.
|
| Telerman A, et al.
|
| Mol Cell Biol 8 : 1498-1503. 1988
|
| 38 | PIM1
|
| Localization of the human pim oncogen (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.
|
| Nagarajan L, et al.
|
| Proc Natl Acad Sci U S A 83 : 2556-2560. 1986
|
| 39 | PIM1
|
| Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6.
|
| Cuypers HT, et al.
|
| Hum Genet 72 : 262-265. 1986
|