| basic FUNCTION
| serine/threonine kinase |
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mediator of cytokine-dependent survival signals in hematopoietic cells |
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has a role in cardioprotection downstream of AKT activation |
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PIM1 and PIM2 play a key role in the v-Abl transformation, possibly via participating in modulation of SOCS1 and via regulating the apoptotic signaling  |
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promote cell cycle progression and tumorigenesis by down-regulating CDKN1B expression at both transcriptional and posttranslational levels |
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phosphorylates MAP3K5 and thus decreases its kinase activity and negatively regulates apoptosis |
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contributes to viral reactivation oby phosphorylating KSHV latency-associated nuclear antigen, LANA |
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implicated in the control of cell cycle progression and apoptosis |
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may act as a sensor for ribosomal stress independently of or in concert with the known TP53-dependent mechanisms |
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contributes to hematopoietic cell growth and survival, although its role is probably secondary to other signaling pathways |
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serine-threonine kinase that has antiapoptotic activity and is involved in cell survival, proliferation, differentiation, transformation, tumor progression, as well as angiogenesis |
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BCL6 and PIM1 are both protooncogenes that play roles in the pathogenesis of lymphoma |
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PIM1 oncogene is required for normal visual function |
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PIM1 activity prevents DNM1L compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to simulated ischemia (sI) |
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PIM1, PIM2, PIM3 have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery |
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involved in several signalling pathways such as the regulation of cell cycle progression and apoptosis |
