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FLASH GENE
Symbol CCND3 contributors: mct - updated : 30-08-2016
HGNC name cyclin D3
HGNC id 1585
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ccnd3
Homologene
FAMILY
  • family of mitogen-activated D-type cyclins
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulator of progression through G1 phase during the cell cycle 3
  • involved in the loss of cell cycle control in a small fraction of malignant glioma
  • having important implications for a role for lamin A/C in muscle differentiation
  • playing a crucial role in adipocyte differentiation by regulating mitotic clonal expansion
  • central coordinator that controls the organization of a complex set of proteins that regulate autophagy, formation of the monocyte-adhesive hyaluronan matrix, and CEBPA-mediated lipogenesis
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • primary driver of the cell cycle, in cooperation with CCND1 that integrates extracellular mitogenic signaling
  • predominantly regulate progression through the cell cycle by their interactions with cyclin-dependent kinases (CDKs)
  • uniquely required for germinal center progression
  • selectively required for proliferative expansion of germinal center B cells
  • primes myoblasts for differentiation by enhancing muscle specific gene expression and cell cycle exit
  • CCND3 and its partner CDK6 were required for the proliferation of Burkitt lymphoma (BL)
  • regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation, thereby controlling erythrocyte size and number
  • likely subnuclear compartmentalization enables CCND3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination
  • critically required for proper developmental progression of myogenic progenitors
  • plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCND3/CDK11A complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK4 and CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex
  • binding to LMNA
  • binding partner of MAPK4
  • key direct target of TCF3 is CCND3, a regulator of the G1-S phase transition that is required for an effective germinal center reaction
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • CCND3 protein that drives immature T cell proliferation is essential for transformation of ATM-deficient thymocytes
  • DYRK1A restrains CCND3 protein levels by phosphorylating T283 to induce its degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with CDKN1B in agressive B cell lymphoma, glioblastoma and gliosarcoma
    tumoral   translocation    
    in multiple myeloma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target for germinal center-derived B-cell malignancies
    ANIMAL & CELL MODELS
    Ccnd3(-/-) mice exhibit a B-cell-intrinsic defect in germinal center maturation and fail to generate an affinity-matured IgG response