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FLASH GENE

Symbol

CSNK2B

contributors: mct - updated : 03-07-2012

HGNC name	casein kinase 2, beta polypeptide
HGNC id	2460

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.19 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
text structure	three transcription initiation site CpG island

MAPPING

cloned

Y

linked

status

confirmed

Map

see PKHD1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001320 7 - 1128 NP_001311 - 215 - 1999 10357806

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       moderately   stomach       moderately Endocrine parathyroid       moderately Lymphoid/Immune lymph node       moderately   tonsils       highly Reproductive female system uterus cervix   moderately   female system ovary     moderately   female system placenta     moderately Skin/Tegument skin       moderately Visual eye       moderately

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a zinc binding region for dimerization

conjugated

PhosphoP

mono polymer

heteromer , tetramer , complex

HOMOLOGY

interspecies	homolog to rattus Csnk2b (100.00 pc)
	homolog to murine Csnk2b (100.00 pc)
	homolog to drosophila CkIIbeta (89.15 pc)

Homologene

FAMILY

casein kinase 2 subunit beta family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	not a casein kinase in vivo, likely involved in regulation of cell growth
	may be involved in cell proliferation through GADD45GIP1 phosphorylation
	role in cell proliferation and anchorage-independent cell growth
	required for CADPS activity
	novel enhancer of ACVRL1 signaling, and important regulator of ACVRL1 signaling and ACVRL1-mediated functions in endothelial cells
	participates in PLK1-WEE1 complex formation interacting directly with WEE1 and thereby contributing to the regulation of G2-M cell cycle transition)
	negative regulator of BMP signaling and osteoblast differentiation
	might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains
	crucial protein involved in the formation and clearance of aggresomes, and hence in cell viability in response to misfolded protein stress
	participates in the regulation of fundamental cellular processes

CELLULAR PROCESS	cell cycle, division
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	insulin mediated cell metabolism and growth

PATHWAY

metabolism

signaling

signal transduction

ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication

a component

a heterotetramer (2A,2B) complexing with the FACT elongation transcription factor made of SSRP1 and FACTP140

INTERACTION

DNA

RNA

small molecule

protein	GADD45GIP1
	CSNK2A1
	CSNK2A2
	LYN
	MBD4
	RPL5
	ZNF44
	ZNHIT1
	ACVRL1/CSNK2B interaction specifically enhanced Smad1/5/8 phosphorylation
	interacting with TNFAIP1 (CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
	binding and regulatory partner for RPS6KA5
	BMP receptor type Ia (BMPR1A) interacting protein
	crucial modulator of HDAC6 activity because CSNK2B directly phosphorylates HDAC6 and increases cytoplasmic deacetylase activity
	interaction partner of the adiponectin receptor 1 (ADIPOR1) N-terminus (interaction of ADIPOR1 with the tetrameric complex and CSNK2B is as a key player in adiponectin signaling)

cell & other

REGULATION

Other

phosphorylated by the alpha chain

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulation of CSNK2B expression might contribute to epithelial to mesenchymal transition induction during cancer progression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS