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Symbol TBP contributors: mct - updated : 28-01-2013
HGNC name TATA box binding protein
HGNC id 11588
Corresponding disease
SCA17 spinocerebellar ataxia 17
Location 6q27      Physical location : 170.863.420 - 170.881.957
Synonym name transcription initiation factor TFIID TBP subunit
Synonym symbol(s) GTF2D, TF2D, GTF2D1, MGC117320, MGC126054, MGC126055, TFIID, SCA17
TYPE functioning gene
STRUCTURE 18.48 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
motif repetitive sequence   triplet
text structure triplet CAG (<42 repeats) in the third exon, a methylation free CpG island spanning their promoter region
MAPPING cloned Y linked N status confirmed
Physical map
MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene DACT2 6q27 dapper homolog 2, antagonist of beta-catenin (xenopus) SMOC2 6q27 SPARC related modular calcium binding 2 LOC346055 6q27 similar to Hypothetical protein CBG10550 THBS2 6q27 thrombospondin 2 LOC391988 6 similar to SPCPB16A4.07c MGC43690 6q27 hypothetical protein MGC43690 PHF10 6q27 PHD finger protein 10 TCTE3 6q27 t-complex-associated-testis-expressed 3 C6orf208 6q27 chromosome 6 open reading frame 208 LOC154449 6q27 hypothetical protein LOC154449 DLL1 6q27 delta-like 1 (Drosophila) KIAA1838 6q27 KIAA1838 PSMB1 7p12 proteasome (prosome, macropain) subunit, beta type, 1 TBP 6q27 TATA box binding protein PDCD2 6q27 programmed cell death 2 LOC391989 6 similar to Olfactory receptor 4F3
regionally located closely linked to PDCD2
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1867 - 339 - 2009 19285969
Type ubiquitous
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
  • a polymorphic polyglutamine (polyQ) domain in its N terminus
  • a DNA-binding domain in its highly conserved C terminus
  • mono polymer monomer
    interspecies homolog to murine Tbp
  • transcription factor (architectural) TF2D family
  • TBP family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • large multiprotein complex, composed of the TATA box-binding protein (TBP) and 14 TBP-associated factors (TAFs), which plays a key role in the regulation of gene expression by RNA polymerase II
  • TBP, BTAF1, and DR1 establish a regulatory circuit that controls downstream core promoter element-dependent versus TATA-dependent transcription b
  • gene transcription in mammalian cells is a dynamic process involving regulated assembly of transcription complexes on chromatin in which TBP plays a central role (PMIS: 20627952)
  • CELLULAR PROCESS nucleotide, transcription, initiation
    a component
  • component of the multisubunit complex TFIID, general transcription factor IID DNA binding subunit
  • s1 also component of TFIIIB and general transcription factor SL1
  • component of the transcription factor
  • SL1/TIFIB complex, composed of TBP and at least TAF1A, TAF1B and TAF1C
  • TBP/GTF2B/Pol II complexes were linked to the production of non-polyadenylated RNA rather than polyadenylated transcripts
  • binds DNA as monomer
  • binds to TATA boxes in core promoters and bends the TATA DNA
  • RNA
    small molecule
  • MYC binding, RUVBL1
  • TATA-box binding
  • DNA binding by TAF4/TAF4B-TAF12 facilitates the association of TBP with the core promoter of a subset of genes
  • BTAF1 negatively regulates TBP and DR1 binding to active promoters
  • interacting with BTAF1 (BTAF1 thus acts as a TBP chaperone to control its interaction with other macromolecules)
  • TBP interacts with NFY subunit A (NFYA), which could be a target of mutant TBP in SCA17
  • H3K4me3, through interactions with TAF3, directs global TBP recruitment
  • H3K4me3 facilitates global TBP recruitment to the core promoters of active genes
  • TAF4 having coactivator function for E proteins that involves enhanced TBP binding
  • may be predominantly crosslinking to GTF2B, rather than directly to the TATA element
  • cell & other
    corresponding disease(s) SCA17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of an N-terminal fragment of the TATA-box binding protein (TBP) in Alzheimer's disease brain tissue
    Susceptibility to type I diabetes( see IDDM8)
    Variant & Polymorphism other CAG/CAA polymorphism in exon 3 associated with diabetes susceptibility
    Candidate gene for mental retardation in the 6q subtelomeric deletion phenotype (DEL6QD)
    Therapy target
  • polyQ expansion causes abnormal interaction of TBP with the general transcription factor TFIIB and induces neurodegeneration in transgenic SCA17 mice
  • chronic alcohol administration in mice leads to enhanced expression of Tbp, Brf1, tRNA, and 5S rRNA gene transcription in the liver