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FLASH GENE

Symbol

MYB

contributors: mct - updated : 14-12-2018

HGNC name	v-myb myeloblastosis viral oncogene homolog (avian)
HGNC id	7545

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   contribute to leukemogenesis tumoral     --over   at relatively high levels in at least two epithelial tumors: colon and breast cancer tumoral     --over   in T cell acute lymphoblastic leukemia constitutional     --over   promotes nuclear accumulation of DHRS2, which is able to support P53 stabilization and activation tumoral fusion translocation     t(6;9)(q23.3;p22.3) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck results in fusions encoding chimeric transcripts predominantly consisting of MYB exon 14 linked to the last coding exon(s) of NFIB constitutional   deletion     in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression tumoral fusion       MYB-GATA1 fusion gene in acute basophilic leukemia tumoral     --over   aberrantly overexpressed in pancreatic cancer cells and acts as a key determinant of pancreatic tumour growth and metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	could be a therapeutic target in human T-ALL

ANIMAL & CELL MODELS