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FLASH GENE

Symbol

IL5

contributors: mct - updated : 08-02-2023

HGNC name	interleukin 5 (colony-stimulating factor, eosinophil)
HGNC id	6016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	2.08 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

the coordinate regulator (LCR) of IL4, IL3 and IL5 is A 0.4kb sequence which is located in the intergenic region between IL4 and IL13 (Loots 00)

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see IRF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000879 4 - 816 NP_000870 13.1 134 - 1993 8483502

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to murine Il5
	ortholog to C.elegans f45g2.8

Homologene

FAMILY

interleukin (IL-5) family

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	colony-stimulating factor (eosinophil and basophil lineages)
	inducing terminal differentiation of B cells to immunoglobulin secreting cells
	IL5 is a T helper 2 cytokine important in the trafficking and survival of eosinophils
	IL5 was found to be responsible for recruitment of eosinophils and tumor-promoting myeloid suppressor cells to malignant pleural effusions (MPE)
	exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils
	IL8, IL6, IL5 might likely play central roles in cytokine storms associated with COVID-19
	IL5 facilitates the recovery of cardiac dysfunction post- myocardial infarction (MI) by promoting eosinophils (EOS) accumulation and subsequent CD206+ macrophage polarization via the IL-4/STAT6 axis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	macrophage IL5 is a target gene for NR1H3 activation, and the induction of macrophage IL5 expression can be related to NR1H3-inhibited atherosclerosis
	IL4 cooperates likely with IL5 to promote eosinophil differentiation
	IL5 suppresses vascular endothelial growth factor-induced angiogenesis through STAT5 signaling
	MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   dysregulation of IL5 production in peripheral blood mononuclear cells (PBMC) in familial eosinophilia (FE)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	the early detection of multiple plasma cytokines might help to predict the prognosis of COVID-19
Therapy target
	System Type Disorder Pubmed allergy asthm   is a suitable target for add-on biological therapies based on IL5 inhibition for patients with severe type 2 (T2)-high eosinophilic asthma, refractory to conventional anti-inflammatory drugs

ANIMAL & CELL MODELS