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FLASH GENE
Symbol IL5 contributors: mct - updated : 08-02-2023
HGNC name interleukin 5 (colony-stimulating factor, eosinophil)
HGNC id 6016
Location 5q31.1      Physical location : 131.877.135 - 131.879.214
Synonym name
  • T-cell replacing factor
  • eosinophil differentiation factor
  • B cell differentiation factor I
    • Synonym symbol(s) E-CSF, EDF, TRF, IL-5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.08 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure the coordinate regulator (LCR) of IL4, IL3 and IL5 is A 0.4kb sequence which is located in the intergenic region between IL4 and IL13 (Loots 00)
    MAPPING cloned Y linked N status confirmed
    Map see IRF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 816 13.1 134 - 1993 8483502
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Il5
    ortholog to C.elegans f45g2.8
    Homologene
    FAMILY interleukin (IL-5) family
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • colony-stimulating factor (eosinophil and basophil lineages)
  • inducing terminal differentiation of B cells to immunoglobulin secreting cells
  • IL5 is a T helper 2 cytokine important in the trafficking and survival of eosinophils
  • IL5 was found to be responsible for recruitment of eosinophils and tumor-promoting myeloid suppressor cells to malignant pleural effusions (MPE)
  • exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils
  • IL8, IL6, IL5 might likely play central roles in cytokine storms associated with COVID-19
  • IL5 facilitates the recovery of cardiac dysfunction post- myocardial infarction (MI) by promoting eosinophils (EOS) accumulation and subsequent CD206+ macrophage polarization via the IL-4/STAT6 axis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • macrophage IL5 is a target gene for NR1H3 activation, and the induction of macrophage IL5 expression can be related to NR1H3-inhibited atherosclerosis
  • IL4 cooperates likely with IL5 to promote eosinophil differentiation
  • IL5 suppresses vascular endothelial growth factor-induced angiogenesis through STAT5 signaling
  • MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    dysregulation of IL5 production in peripheral blood mononuclear cells (PBMC) in familial eosinophilia (FE)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • the early detection of multiple plasma cytokines might help to predict the prognosis of COVID-19
    • Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    is a suitable target for add-on biological therapies based on IL5 inhibition for patients with severe type 2 (T2)-high eosinophilic asthma, refractory to conventional anti-inflammatory drugs
    ANIMAL & CELL MODELS