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FLASH GENE

Symbol

PRDM1

contributors: mct/ - updated : 09-10-2015

HGNC name	PR domain containing 1, with ZNF domain
HGNC id	9346

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     deleted in several B-cell non Hodgkin lymphoma and other cancers tumoral somatic mutation       in B-cell lymphoma tumoral     --other   disruption of homeostatic control by PRDM1 may be an important pathogenetic mechanism for natural killer cell lymphoma

Susceptibility

to systemic lupus erythematosus to therapy-induced second malignancies after Hodgkin lymphoma

Variant & Polymorphism other	variant (rs6568431) identified in an intergenic region between PRDM1 and ATG5 (APG5 autophagy 5-like) associated to to systemic lupus erythematosus
	variants implicated in the etiology of therapy-induced second malignancies after Hodgkin lymphoma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in the Prdm1 conditional knockout (CKO) retina, the number of photoreceptor cells was markedly reduced in the differentiated retina