| 1 | ELL2, PRDM1
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| Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.
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| Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, Tarakhovsky A, Nutt SL, Jaritz M, Busslinger M.
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| Nat Immunol at Immunol. 2016 Jan 18. doi: 10.1038/ni.3349. [Epub ahead of print]
2016
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| 2 | PRDM1, TAX1BP1
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| Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
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| Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.
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| Sci Rep 6:31266. doi: 10.1038/srep31266.
2016
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| 3 | IFNG, PRDM1, TLE4
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| Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.
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| Bandyopadhyay S, Valdor R, Macian F.
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| Mol Cell Biol 34(2):233-45. doi: 10.1128/MCB.00902-13. Epub 2013 Nov 4. 2014
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| 4 | BACH2, PRDM1
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| Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network.
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| Igarashi K, Ochiai K, Itoh-Nakadai A, Muto A.
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| Immunol Rev 261(1):116-25. doi: 10.1111/imr.12201.
2014
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| 5 | ETS1, IL2, NFATC1, PRDM1
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| Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
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| Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC, Ho IC.
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| Proc Natl Acad Sci U S A 110(39):15776-81. doi: 10.1073/pnas.1304343110. Epub 2013 Sep 9. 2013
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| 6 | CD40LG, IL21, PRDM1
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| IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
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| Ding BB, Bi E, Chen H, Yu JJ, Ye BH.
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| J Immunol 190(4):1827-36. doi: 10.4049/jimmunol.1201678. Epub 2013 Jan 16.
2013
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| 7 | EBF1, PRDM1
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| EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells.
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| Kikuchi H, Nakayama M, Takami Y, Kuribayashi F, Nakayama T.
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| Biochem Biophys Res Commun 422(4):780-5. Epub 2012 May 24.
2012
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| 8 | PRDM1, SUMO1
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| SUMOylation of Blimp-1 is critical for plasma cell differentiation.
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| Ying HY, Su ST, Hsu PH, Chang CC, Lin IY, Tseng YH, Tsai MD, Shih HM, Lin KI.
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| EMBO Rep 13(7):631-7. doi: 10.1038/embor.2012.60.
2012
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| 9 | PRDM1
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| Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.
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| Morgan MA, Mould AW, Li L, Robertson EJ, Bikoff EK.
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| Mol Cell Biol 32(17):3403-13. doi: 10.1128/MCB.00174-12. Epub 2012 Jun 25.
2012
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| 10 | ICOSLG, PRDM1, TNFRSF13B, TNFSF13B
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| Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.
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| Ou X, Xu S, Lam KP.
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| Proc Natl Acad Sci U S A 109(38):15401-6.
2012
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| 11 | IRF2, PRDM1
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| IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms.
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| Minamino K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S, Inaba K.
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| Int Immunol 24(9):573-81. doi: 10.1093/intimm/dxs060. Epub 2012 Jul 5.
2012
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| 12 | PRDM1, ZFP36L1
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| ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA.
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| Nasir A, Norton JD, Baou M, Zekavati A, Bijlmakers MJ, Thompson S, Murphy JJ.
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| PLoS One. (12):e52187. doi: 10.1371/journal.pone.0052187. Epub 2012 Dec 20 2012
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| 13 | PRDM1
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| SUMOylation of Blimp-1 promotes its proteasomal degradation.
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| Shimshon L, Michaeli A, Hadar R, Nutt SL, David Y, Navon A, Waisman A, Tirosh B.
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| FEBS Lett 585(15):2405-9. Epub 2011 Jun 25.
2011
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| 14 | PRDM1
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| A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
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| Kallies A, Carotta S, Huntington ND, Bernard NJ, Tarlinton DM, Smyth MJ, Nutt SL.
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| Blood 117(6):1869-79. Epub 2010 Dec 3.
2011
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| 15 | PRDM1
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| Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses.
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| Karube K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, Shimizu N, Ko YH, Morishima Y, Ohshima K, Nakamura S, Seto M.
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| Blood 118(12):3195-204. Epub 2011 Jun 20.
2011
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| 16 | PRDM1
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| Tolerogenic function of Blimp-1 in dendritic cells.
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| Kim SJ, Zou YR, Goldstein J, Reizis B, Diamond B.
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| J Exp Med 208(11):2193-9. Epub 2011 Sep 26. Erratum in: J Exp Med. 2012 Feb 13;209(2):425.
2011
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| 17 | PRDM1, TNFSF9
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| PRDM1 is a tumor suppressor gene in natural killer cell malignancies.
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| Küçük C, Iqbal J, Hu X, Gaulard P, De Leval L, Srivastava G, Au WY, McKeithan TW, Chan WC.
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| Proc Natl Acad Sci U S A 108(50):20119-24. Epub 2011 Dec 5.
2011
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| 18 | IRF4, PRDM1
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| The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.
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| Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz GT, Smyth GK, Busslinger M, Nutt SL, Kallies A.
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| Nat Immunol 12(4):304-11. Epub 2011 Mar 6.
2011
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| 19 | PRDM1
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| Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma.
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| Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K.
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| Nat Med 17(8):941-3. doi: 10.1038/nm.2407.
2011
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| 20 | PRDM1, TNFRSF13B
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| TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow.
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| Tsuji S, Cortesão C, Bram RJ, Platt JL, Cascalho M.
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| Blood 118(22):5832-9. doi: 10.1182/blood-2011-05-353961. Epub 2011 Oct 7.
2011
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| 21 | NFATC1, PRDM1, TM7SF4
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| Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
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| Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H.
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| Proc Natl Acad Sci U S A 107(7):3117-22. Epub 2010 Jan 28.PMID: 20133620 2010
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| 22 | IRF4, IRF5, IRF8, PRDM1
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| Critical role of IRF-5 in regulation of B-cell differentiation.
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| Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM.
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| Proc Natl Acad Sci U S A 107(10):4664-8. Epub 2010 Feb 22. 2010
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| 23 | PRDM1
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| An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression.
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| Doody GM, Care MA, Burgoyne NJ, Bradford JR, Bota M, Bonifer C, Westhead DR, Tooze RM.
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| Nucleic Acids Res 38(16):5336-50. Epub 2010 Apr 26. 2010
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| 24 | PRDM1, VSX2
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| Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.
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| Katoh K, Omori Y, Onishi A, Sato S, Kondo M, Furukawa T.
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| J Neurosci 30(19):6515-26.
2010
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| 25 | PRDM1, VSX2
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| Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.
|
| Brzezinski JA 4th, Lamba DA, Reh TA.
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| Development 137(4):619-29.
2010
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| 26 | BACH2, PRDM1
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| Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch.
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| Muto A, Ochiai K, Kimura Y, Itoh-Nakadai A, Calame KL, Ikebe D, Tashiro S, Igarashi K.
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| EMBO J 29(23):4048-61. Epub 2010 Oct 15.
2010
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| 27 | BRD7, PRDM1
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| Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
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| Burrows AE, Smogorzewska A, Elledge SJ.
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| Proc Natl Acad Sci U S A 107(32):14280-5. Epub 2010 Jul 26.
2010
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| 28 | MYD88, PRDM1
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| The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.
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| He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A.
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| Nat Immunol 11(9):836-45. doi: 10.1038/ni.1914. Epub 2010 Aug 1.
2010
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| 29 | KDM1A, PRDM1
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| Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation.
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| Su ST, Ying HY, Chiu YK, Lin FR, Chen MY, Lin KI.
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| Mol Cell Biol 29(6):1421-31. Epub 2009 Jan 5. 2009
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| 30 | PRDM1
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| An expanding job description for Blimp-1/PRDM1.
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| Bikoff EK, Morgan MA, Robertson EJ.
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| Curr Opin Genet Dev 19(4):379-85. Epub 2009 Jul 9.
2009
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| 31 | BCL6, PRDM1
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| Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
|
| Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S.
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| Science 325(5943):1006-10. Epub 2009 Jul 16.
2009
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| 32 | IL10, JAZF1, PRDM1, TNIP1, UHRF1BP1
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| A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
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| Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G Jr, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, Graham RR.
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| Nat Genet 41(11):1228-33. Epub 2009 Oct 18.PMID: 19838195 2009
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| 33 | IDO1, PRDM1
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| Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase.
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| Barnes NA, Stephenson SJ, Tooze RM, Doody GM.
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| J Immunol 183(9):5768-77. Epub 2009 Oct 14.PMID: 19828629 2009
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| 34 | PRDM1
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| Novel BLIMP1/PRDM1 gene mutations in B-cell lymphoma.
|
| Tate G, Hirayama-Ohashi Y, Kishimoto K, Mitsuya T.
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| Cancer Genet Cytogenet 172(2):151-3.
2007
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| 35 | PRDM1
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| Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown.
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| Lin FR, Kuo HK, Ying HY, Yang FH, Lin KI.
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| Cancer Res 67(24):11914-23.
2007
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| 36 | PRDM1
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| Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.
|
| Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV, Aster JC, Murty VV, Shipp MA, Dalla-Favera R.
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| J Exp Med 203(2):311-7. 2006
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| 37 | PRDM1
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| Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas.
|
| Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM.
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| Blood 107(10):4090-100. Epub 2006 Jan 19. 2006
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| 38 | PRDM1, PRDM2
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| Characterization of the PR domain of RIZ1 histone methyltransferase.
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| Derunes C, Briknarova K, Geng L, Li S, Gessner CR, Hewitt K, Wu S, Huang S, Woods VI Jr, Ely KR.
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| Biochem Biophys Res Commun 333(3):925-34. 2005
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| 39 | PRDM1
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| Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells.
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| Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, Calame K.
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| Immunity 19(4):607-20. 2003
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| 40 | PRDM1
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| Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines.
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| Gyory I, Fejer G, Ghosh N, Seto E, Wright KL.
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| J Immunol 170(6):3125-33. 2003
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| 41 | BCL6, JUN, JUNB, PRDM1
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| Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.
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| Vasanwala FH, Kusam S, Toney LM, Dent AL.
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| J Immunol 169(4):1922-9. 2002
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| 42 | PRDM1
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| PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.
|
| Ren B, et al.
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| Genes Dev 13(1):125-37. 1999
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| 43 | PRDM1, TSG6F
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| The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10.
|
| Mock BA, et al.
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| Genomics 37 : 24-28. 1996
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| 44 | PRDM1, ST8, TSG6F
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| Localization by chromosome microdissection of a recurrent breakpoint region on chromosome 6 in human B-cell lymphoma.
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| Guan XY, et al.
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| Blood 88 : 1418-1422. 1996
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| 45 | PRDM1, ST8, TSG6F
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| Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.
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| Gaidano G, et al.
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| Blood 80 : 1781-1787. 1992
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| 46 | PRDM1
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| Identification and characterization of a novel repressor of beta-interferon gene expression.
|
| Keller AD, et al.
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| Genes Dev 5 : 868-879. 1991
|