| protein
| NCAM1 |
|
receptor for FGF9 in the XY gonad |
|
interaction of FRS2 with wild-type receptor occurs primarily at the vesicular membrane, whereas the interaction with the P253R receptor occurs exclusively at the plasma membrane  |
|
MMP14 is a critical negative modulator of ADAM9 activity to maintain FGFR2 signaling in calvarial osteogenesis |
|
upon stimulation, FGFR2 phosphorylates tyrosine residues on GRB2, promoting dissociation from the receptor and allowing full |
|
co-localization of NCAM1 and FGFR2 in early vertebrate development with intracellular signaling pathways present to enable a cellular response |
|
activation of downstream signaling, establishing a role for GRB2 as an active regulator of RTK signaling |
|
GRB2 is strongly implicated in controlling FGFR2 kinase activity prior to growth factor stimulation |
|
FGFR2 induces rapid but reversible NANOG repression within ES cells |
|
HOXC6 play an important role in several cellular events through the regulation of its functional biological targets such as BMP7, FGFR2, and PDGFRA |
|
FGFR2 serves as a scaffold for multiple components of the NFKB1 signaling complex |
|
GRB2 controls FGFR2 signaling by regulating receptor kinase and PTPN11 phosphatase activity in the absence of extracellular stimulation |
|
LDB1 in a complex with LMO4, supports mammary stem cells by directly targeting the FGFR2 promoter in basal cells to increase its expression |
|
key roles played, on the melanosome transfer in normal skin, by FGF7 released by dermal fibroblasts and by its receptor FGFR2 expressed and activated on the epidermal keratinocytes |
|
potential role for NEGR1 in regulating neurite outgrowth through the modulation of FGFR2 signaling pathway |
|
FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2 |
|
DDX6 protein acted as an RNA-binding protein for ERBB2 and FGFR2 mRNAs and positively regulated their post-transcriptional processes |
|
NEGR1 and FGFR2 cooperatively regulate cortical development, suggesting a role for defective NEGR1-FGFR2 complex and convergent downstream ERK and AKT signalling in autism spectrum disorders |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| somatic mutation
|
|
|
| |
in gastric carcinoma | | tumoral
| germinal mutation
|
|
|
| |
mutation P253R in early-onset low-grade papillary carcinoma of the bladder associated with Apert syndrome | | tumoral
|
|
| --low
|
| |
by hypermethylation in gastric cancer cells, contributing to tumor progression | | tumoral
|
| amplification
| --over
|
| |
in breast cancer | | tumoral
| somatic mutation
|
|
|
| |
in endometrial cancer | | tumoral
|
| amplification
|
|
| |
in diffuse-type gastric cancer | | constitutional
|
| deletion
|
|
| |
of either FGF9 or FGFR2 in an XY gonad resulted in up-regulation of WNT4 and male-to-female sex reversal | | constitutional
|
|
| --over
|
| |
increased FGFR2 activation during embryonic period leads to abnormal differentiation or regression of the tail bud and, in turn, sacrococcygeal eversion, in certain patients with severe syndromic craniosynostosis | | tumoral
|
|
| --over
|
| |
in pancreatic ductal adenocarcinoma (PDAC) and correlated with advanced stage cancer | | tumoral
| fusion
|
|
|
| |
KLK2-FGFR2 fusion gene in metastatic prostate cancer | |
