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FLASH GENE
Symbol FOXI1 contributors: - updated : 23-05-2007
HGNC name forkhead box I1
HGNC id 3815
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain
  • with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    ortholog to murine Fkhl10
    Homologene
    FAMILY HNF-3 forkhead family of transcriptional activator
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator necessary for the development of both cochlea and vestibulum
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text inner ear
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein transcriptional activator of SLC26A4
    cell & other
    REGULATION
    Other maybe associated with the common cavity phenotype
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in Pendred syndrome
    constitutional germinal mutation      
    in hearing loss associated with enlarged vestibular aqueduct (DFNB4)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice with a targetted disruption of Frhl10 have a gross structural malformation of the cochlea and vestibulum replaced by a single irregular cavity