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FLASH GENE
Symbol MICB contributors: mct - updated : 22-04-2013
HGNC name MHC class I polypeptide-related sequence B
HGNC id 7091
Location 6p21.33      Physical location : 2.751.270 - 31.478.898
Synonym name
  • perth beta block transcript 11.2
  • MHC class I mic-B antigen
  • stress inducible class I homolog
  • MHC class I-like molecule PERB11.2-IMX
    • Synonym symbol(s) PERB11.2, MIC-B
    DNA
    TYPE functioning gene
    STRUCTURE 12.94 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see LTA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2497 42.4 383 - 1998 9480751
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Endocrinepancreas    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
  • MIC subfamily
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the presentation of foreign antigens to the immune system
  • MICA, and MICB, ligands of the KLRK1, which activates NK cells and costimulates effector T cells, are inducibly expressed under harmful conditions, such as malignancies and microbial infections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • synergistic activity of two stress-inducible immunological danger signals, HSP70 and MICA/MICB, leads to activation and enhanced cytotoxicity of human NK cells against tumour cells
  • IGF2BP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULBP2 and MICB
    • cell & other
    REGULATION
    Other activation of MICA and MICB is the result of DNA damage response activation caused by DICER1 knockdown
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment
    Susceptibility
  • to rheumatoid arthritis (RA)
  • to dengue shock syndrome
    • Variant & Polymorphism SNP
  • MICB*004 allele was associated with RA susceptibility
  • variant increasing susceptibility for dengue shock syndrome
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS