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FLASH GENE
Symbol SLC6A7 contributors: mct - updated : 16-02-2008
HGNC name solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
HGNC id 11054
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 transmembrane segments (12TM)
    • HOMOLOGY
    Homologene
    FAMILY
  • sodium:neurotransmitter symporter (SNF) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text located in synaptosomal membranes
    basic FUNCTION
  • Na+ (and Cl-) dependent plasma membrane transporter of proline, high affinity
  • playing a presynaptic regulatory role in excitatory synaptic transmission
  • transporter for an excitatory neurotransmitter of L-proline
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma
    Variant & Polymorphism other significant associations between genetic variants of the SLC6A7 gene and asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS