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FLASH GENE

Symbol

SLC6A7

contributors: mct - updated : 16-02-2008

HGNC name	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
HGNC id	11054

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	21.12 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014228 14 - 3756 NP_055043 70.8 636 - PMID: 20431603

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

12 transmembrane segments (12TM)

HOMOLOGY

Homologene

FAMILY

sodium:neurotransmitter symporter (SNF) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	located in synaptosomal membranes

basic FUNCTION	Na+ (and Cl-) dependent plasma membrane transporter of proline, high affinity
	playing a presynaptic regulatory role in excitatory synaptic transmission
	transporter for an excitatory neurotransmitter of L-proline

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma

Variant & Polymorphism other	significant associations between genetic variants of the SLC6A7 gene and asthma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS