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FLASH GENE
Symbol SDHA contributors: mct - updated : 07-01-2014
HGNC name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
HGNC id 10680
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • characteristic cysteine triplet FAD binding domain
    • HOMOLOGY
    interspecies homolog to C.elegans c03g5.1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the seventh step of the citric acid cycle, i.e. oxidation of succinate to fumarase
  • play a role in mitochondrial oxidative phosphorylation
  • a crucial dosage-dependent role for SDHA, SDHB in oxygen homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex II of mitochondrial respiratory chain, oxidative phosphorylation,(OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDHA and SDHB interacted specifically with SIRT3 (SIRT3 may be an important physiological regulator of SDH activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SDHAD , PGL5 , CMD1GG
    Susceptibility to oligospermia
    Variant & Polymorphism SNP SDHA c.456+32G>A) showed significant genotype association with impairment of sperm production
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS