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FLASH GENE
Symbol SDHA contributors: mct - updated : 07-01-2014
HGNC name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
HGNC id 10680
Corresponding disease
CMD1GG cardiomyopathy, dilated, 1GG
PGL5 hereditary paraganglioma 5
SDHAD succinate CoQ reductase deficiency
Location 5p15.33      Physical location : 218.355 - 256.812
Synonym name flavoprotein subunit of complex II
Synonym symbol(s) FPJ, SDH2, SDHF, FP, SDH1, CMD1GG
EC.number 1.3.5.1
DNA
TYPE functioning gene
STRUCTURE 38.46 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
ZFP62 5q35.3 zinc finger protein 62 homolog (mouse) LOC389256 5 similar to hypothetical protein D630003M21 KIAA1909 5p15.33 KIAA1909 protein LOC389257 5 similar to Hypothetical protein KIAA0014 LOC133957 5p15.33 similar to RIKEN cDNA 0610011N22 SDHA 5p15 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) PDCD6 5pter programmed cell death 6 LOC389258 5 similar to protein phosphatase 4, regulatory subunit 2 LOC391733 5 similar to Microneme antigen AHRR 5p15.3 aryl-hydrocarbon receptor repressor SEC6 SLC9A3 5p15.3 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 LOC389259 5 LOC389259 FLJ20413 5p15.33 hypothetical protein FLJ20413 FLJ10565 5p15.33 hypothetical protein FLJ10565 p25 5p15.3 brain-specific protein p25 alpha LOC389260 5 similar to zinc finger, DHHC domain containing 11 LOC389261 5 similar to hypothetical protein ZDHHC11 5p15.2 zinc finger, DHHC domain containing 11 FLJ13441 TRIP13 5p15.2 thyroid hormone receptor interactor 13 LOC389262 5 LOC389262 NKD2 5p15.3 naked cuticle homolog 2 (Drosophila) SLC12A7 5p15.3 solute carrier family 12 (potassium/chloride transporters), member 7 LOC389263 5 hypothetical gene supported by AK096096 LOC340024 5p15.33 hypothetical protein LOC340024 FLJ31236 5p15.33 hypothetical protein FLJ31236 TERT 5p15.33 telomerase reverse transcriptase CRR9 5pter-p15.3 cisplatin resistance related protein CRR9p SLC6A3 5p15.3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 FLJ12443 5p15.33 hypothetical protein FLJ12443 LOC389264 5 LOC389264 LOC340026 5p15.33 similar to succinate dehydrogenase flavoprotein subunit LOC389265 5 hypothetical gene supported by NM_174907 LOC389266 5 LOC389266 MRPL36 5p15.3 mitochondrial ribosomal protein L36 NDUFS6 5pter-p15.33 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) LOC389267 5 similar to antifreeze glycoprotein precursor - black rockcod IRX4 5p15.3 iroquois homeobox protein 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2405 - 664 cervical carcinoma and paraganglioma 2007 17376234
- - - - - in the Burkitt lymphoma and paraganglioma 2005 16195397
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • characteristic cysteine triplet FAD binding domain
  • HOMOLOGY
    interspecies homolog to C.elegans c03g5.1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the seventh step of the citric acid cycle, i.e. oxidation of succinate to fumarase
  • play a role in mitochondrial oxidative phosphorylation
  • a crucial dosage-dependent role for SDHA, SDHB in oxygen homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex II of mitochondrial respiratory chain, oxidative phosphorylation,(OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDHA and SDHB interacted specifically with SIRT3 (SIRT3 may be an important physiological regulator of SDH activity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SDHAD , PGL5 , CMD1GG
    Susceptibility to oligospermia
    Variant & Polymorphism SNP SDHA c.456+32G>A) showed significant genotype association with impairment of sperm production
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS